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Pre-Clinical Models of Heart Failure with Preserved Ejection Fraction: Advancing Knowledge for Device Based Therapies
Nina Langer1,2, Andreas Escher3, Caglar Ozturk4
1Department of Mechanical and Aerospace Engineering, Monash University, Melbourne, VIC, Australia. nina.langer@monash.edu.
Annals of Biomedical Engineering
|August 25, 2025
Summary
Heart failure with preserved ejection fraction (HFpEF) is a growing global health issue. This review examines preclinical models to improve diagnosis and develop effective device therapies for HFpEF.
Area of Science:
- Cardiology
- Biomedical Engineering
Background:
- Heart failure with preserved ejection fraction (HFpEF) affects half of all heart failure cases globally.
- Diverse patient presentations complicate HFpEF diagnosis and treatment.
- Current treatments for HFpEF show limited efficacy due to patient heterogeneity.
Purpose of the Study:
- To review current preclinical models for HFpEF.
- To assess the utility of these models in advancing HFpEF understanding and device therapy development.
Main Methods:
- Overview of in-silico, in-vitro, ex-vivo, and in-vivo preclinical models.
- Evaluation of each model's capacity to replicate HFpEF characteristics.
- Discussion of model strengths, limitations, and clinical relevance.
Main Results:
- Preclinical models are crucial for understanding HFpEF pathophysiology.
- Various models offer distinct advantages for studying HFpEF.
- No single model fully captures HFpEF complexity, necessitating combined approaches.
Conclusions:
- Improved preclinical models are essential for developing effective device-based therapies for HFpEF.
- Further research into emerging model advancements is warranted.
- These models will guide the creation of clinically relevant HFpEF solutions.
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