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Updated: Sep 10, 2025

A Microwave-Assisted Direct Heteroarylation of Ketones Using Transition Metal Catalysis
Published on: February 16, 2020
Irradiation of Bifunctional Masked Ketone Pro-Aromatics Unveils Autoinductive Autocatalysis via Electron
Cheng-Lin Chan1, Yong-Ting Tsao1, Aira Shayne Paculba1
1Department of Chemistry, National Sun Yat-sen University, Kaohsiung 804201, Taiwan (R.O.C.).
Abstract:
We disclose an autocatalytic electron donor-acceptor (EDA) strategy by reutilizing redox auxiliary byproducts as in situ acceptors, enabling an external initiator-free activation of pro-aromatic dihydroquinazolinones (DHQZs). Spectroscopic and DFT data support the Lewis acid-enhanced aggregate formation where DHQZ serves as both donor and latent acceptor through its quinazolinone byproduct. Kinetic studies reveal a kinetic profile specifically representing autoinductive autocatalysis. This platform enables Giese-type acylation/alkylation, desulfonylation, and Minisci reactions, forging C-C, C-N, C-S, and C-Se bonds under mild conditions.
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