Mapping the evolving trend of research on efferocytosis: a comprehensive data-mining-based study

Area of Science:

• Immunology and Cell Biology
• Biomedical Research

Background:

• Efferocytosis, the removal of apoptotic cells by phagocytes, is crucial for tissue homeostasis and immune regulation.
• Research into efferocytosis's molecular mechanisms and clinical relevance has significantly increased.
• This bibliometric analysis maps the field's evolution, key players, and emerging themes.

Purpose of the Study:

• To analyze publication trends, citation networks, and keyword co-occurrence in efferocytosis research from 2006-2024.
• To identify leading authors, institutions, and countries contributing to the field.
• To outline current research foci and predict future hot topics in efferocytosis.

Main Methods:

• A comprehensive literature search was performed on the Web of Science database.
• Data from 1549 publications (2006-2024) were analyzed using CiteSpace and VOSviewer.
• Bibliometric indicators including publication volume, geographical distribution, and keyword analysis were employed.

Main Results:

• Publication output on efferocytosis shows a steady increase, especially in the last decade.
• China and the United States are the top contributing countries, with Harvard University leading in institutional output.
• Current research focuses on molecular mechanisms, inflammation, and therapeutic applications in diseases like atherosclerosis and cardiovascular disease. Emerging themes include neuroinflammation, immunometabolism, and aging.

Conclusions:

• This bibliometric analysis offers a comprehensive overview of the efferocytosis research landscape.
• The findings highlight significant progress and identify key areas for future investigation.
• This study serves as a guide for research and policy aimed at leveraging efferocytosis for therapeutic advancements.