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[Space magnetic environment and circadian rhythm].

Bing-Xin Gao1, Cao Wang1, Rui-Xian Jiang1

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Sheng Li Xue Bao : [Acta Physiologica Sinica]
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Space magnetic fields disrupt astronaut circadian rhythms by affecting mitochondria, impacting health and mission performance. This review explores simulation technologies and mechanisms to develop protective strategies.

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Area of Science:

  • Space biology
  • Chronobiology
  • Aerospace medicine

Background:

  • China's space program advances, increasing astronaut exposure to space magnetic fields.
  • Space magnetic fields impact mitochondrial function, disrupting circadian rhythms and astronaut health.
  • Inconsistent research findings necessitate a systematic review due to varied experimental parameters.

Purpose of the Study:

  • To review ground-based simulation technologies for space magnetic fields.
  • To summarize the effects of magnetic fields on circadian rhythm biomarkers.
  • To explore molecular and physiological mechanisms of magnetic field-induced circadian disruption.

Main Methods:

  • Systematic review of existing literature.
  • Analysis of ground-based simulation technologies.
  • Examination of molecular and physiological mechanisms.

Main Results:

  • Space magnetic fields interfere with mitochondrial electron transport, ATP synthesis, and reactive oxygen species (ROS) balance.
  • Disruption leads to circadian misalignment, sleep disorders, and metabolic dysregulation.
  • Varied magnetic field parameters and experimental models contribute to inconsistent research outcomes.

Conclusions:

  • Understanding magnetic field effects on circadian rhythms is crucial for astronaut health.
  • Developing adaptive protective strategies based on circadian regulation is essential for long-term space missions.
  • This review provides a scientific basis for mitigating space magnetic field impacts on astronauts.