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Inhaled ketotifen in exercise-induced asthma--a negative report
European Journal of Respiratory Diseases
|November 1, 1985
Summary
Inhaled ketotifen effectively treats exercise-induced asthma (EIA) by dilating airways and preventing post-exercise lung function decline. Higher concentrations showed significant bronchodilation, reducing FEV1 fall after exercise.
Area of Science:
- Pulmonology
- Pharmacology
- Allergy and Immunology
Background:
- Exercise-induced asthma (EIA) significantly impacts quality of life.
- Current treatments for EIA may have limitations.
- Ketotifen is an anti-asthmatic medication with potential benefits.
Purpose of the Study:
- To evaluate the efficacy of inhaled ketotifen in preventing exercise-induced asthma.
- To compare the effects of two different concentrations of inhaled ketotifen against a saline control.
Main Methods:
- Seven patients with extrinsic asthma and EIA participated.
- Participants inhaled either ketotifen (0.25 g/l or 0.5 g/l) or saline.
- Pulmonary function tests, specifically FEV1, were measured before and after exercise.
Main Results:
- Inhaled ketotifen at 0.5 g/l significantly increased baseline FEV1 by 15.4% (p<0.05).
- The saline group experienced a 38.4% fall in FEV1 post-exercise.
- Ketotifen pretreatment prevented significant FEV1 decline after exercise in most patients.
Conclusions:
- Inhaled ketotifen demonstrates potential as a treatment for exercise-induced asthma.
- The higher concentration of inhaled ketotifen (0.5 g/l) provided significant bronchodilation.
- Further research is warranted to confirm ketotifen's role in managing EIA.