[An Immune-Mediated Vortex: Hepatic Autoimmune Overlap, Pancytopenia, and Enteritis in a Patient with Systemic Lupus...

Systemic lupus erythematosus (SLE) is a chronic multisystem inflammatory disease with a wide spectrum of clinical manifestations. Its association with autoimmune hepatitis is well documented; however, there is limited evidence linking it to hepatic overlap syndromes involving primary sclerosing cholangitis. Although cytopenias are a common hematologic manifestation of SLE, pancytopenia is less frequent and is associated with increased morbidity. Lupus enteritis is an uncommon gastrointestinal manifestation, typically presenting with nonspecific symptoms, which necessitates a high index of clinical suspicion for timely diagnosis. In this article, we present the clinical case of a patient with multiple coexisting autoimmune conditions consistent with SLE, who showed favorable clinical evolution following the initiation of immunosuppressive therapy.