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Published on: June 21, 2017
Copper-Catalyzed Transfer Markovnikov Hydrothiolation of Alkenes
Zhen Wang1, Luomo Li1, Xiao-Hui Yang1,2
1Advanced Research Institute of Multidisciplinary Science, and School of Chemistry and Chemical Engineering, Beijing Institute of Technology, Beijing 100081, P. R. China.
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A copper(II) triflate catalyzed transfer hydromethylthiolation of alkenes has been developed using commercially available and easy-to-handle β-methylthioketone as the methanethiol donor under air. This method exclusively provides Markovnikov products. The reaction demonstrates a broad substrate scope and excellent functional group tolerance, including compatibility with natural product derivatives. Furthermore, methylthioethers synthesized by this protocol were successfully applied to the preparation of diverse sulfur-containing compounds as well as bioactive molecules.
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