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Bronsted-Lowry Acids and Bases

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The acid-base reaction class has been studied for quite some time. In 1680, Robert Boyle reported traits of acid solutions that included their ability to dissolve many substances, to change the colors of certain natural dyes, and to lose these traits after coming in contact with alkali (base) solutions. In the eighteenth century, it was recognized that acids have a sour taste, react with limestone to liberate a gaseous substance (now known to be CO2), and interact with alkalis to form neutral...

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Updated: Jun 26, 2026

Affinity Precipitation of Active Rho-GEFs Using a GST-tagged Mutant Rho Protein (GST-RhoA(G17A)) from Epithelial Cell Lysates

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Published on: March 31, 2012

Rh-Catalyzed Intermolecular Asymmetric Hydrofunctionalization of Alkenes.

Bowen Zheng¹, Binglin Wang¹, Yaoxin Wang¹

¹School of Interdisciplinary Science, Key Laboratory of Medical Molecule Science and Pharmaceutical Engineering, Ministry of Industry and Information Technology, School of Chemistry and Chemical Engineering, Beijing Institute of Technology, Beijing 100081, P. R. China.

The Journal of Organic Chemistry

|March 3, 2026

Summary

This review explores Rh-catalyzed asymmetric alkene hydrofunctionalization, a key method for creating chiral molecules with diverse heteroatoms. It highlights advances in synthesizing complex organic compounds efficiently and stereoselectively.

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Published on: October 6, 2023

Area of Science:

Organic Chemistry
Catalysis
Synthetic Methodology

Background:

Rh-catalyzed asymmetric hydrofunctionalization of alkenes is crucial for synthesizing chiral heteroatom-containing compounds.
This method offers high atom economy, regioselectivity, and stereocontrol.

Purpose of the Study:

To systematically review recent advances in Rh-catalyzed enantioselective alkene hydrofunctionalization.
To cover elements from Groups 13 to 16, focusing on ligand design, reaction scope, and applications.

Main Methods:

Summarizing recent literature on Rh-catalyzed asymmetric hydrofunctionalization of alkenes.
Organizing findings based on main-group element categories (Groups 13-16).

Main Results:

Detailed overview of Rh-catalyzed enantioselective hydrofunctionalization involving B, Si, N, O, S, and Se.
Emphasis on ligand design, reaction diversity, substrate scope, and synthetic utility.

Conclusions:

Rh-catalyzed hydrofunctionalization is a powerful tool for accessing chiral molecular architectures.
Identifies current challenges and outlines future research directions in the field.