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DYNAFormer: Enhancing transformer segmentation with dynamic anchor mask for medical imaging
Tan-Cong Nguyen1, Kim Anh Phung2, Thao Thi Phuong Dao3
1University of Science, VNU-HCM, Ho Chi Minh City, Viet Nam; University of Social Sciences and Humanities, VNU-HCM, Ho Chi Minh City, Viet Nam; Vietnam National University, Ho Chi Minh City, Viet Nam.
Computers in Biology and Medicine
|August 26, 2025
Summary
This study introduces DYNAFormer, a novel AI model for segmenting colorectal polyps, and PolypDB_INS, a new dataset. DYNAFormer significantly improves polyp diagnosis and colorectal cancer risk assessment.
Area of Science:
- Medical Imaging
- Artificial Intelligence
- Computer Vision
Background:
- Accurate segmentation of colorectal polyps, particularly sessile and pedunculated types, is crucial for cancer diagnosis and risk assessment.
- Existing datasets and models have limitations in segmenting these specific polyp shapes, hindering diagnostic accuracy.
Purpose of the Study:
- To introduce PolypDB_INS, a comprehensive dataset for polyp segmentation.
- To propose DYNAFormer, a novel transformer-based model for enhanced polyp segmentation.
- To improve the accuracy of colorectal polyp diagnosis and cancer risk assessment through advanced AI.
Main Methods:
- Development of PolypDB_INS dataset with 4403 images and 4918 annotated sessile and pedunculated polyps.
- Proposal of DYNAFormer, a transformer model employing anchor mask-guided mechanisms, cross-attention, dynamic query updates, and query denoising.
- Evaluation using standard instance and semantic segmentation metrics on the PolypDB_INS dataset.
Main Results:
- DYNAFormer demonstrated significant performance improvements over state-of-the-art methods in polyp segmentation.
- Ablation studies validated the effectiveness of the individual components within the DYNAFormer model.
- The model's robustness in segmenting complex polyp structures was confirmed, aiding in diagnostic capabilities.
Conclusions:
- The PolypDB_INS dataset and DYNAFormer model offer a robust solution for colorectal polyp segmentation.
- The proposed methods enhance the precision of polyp diagnosis, contributing to better colorectal cancer risk assessment.
- The developed AI tools show promise for clinical application in gastroenterology and oncology.

