Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Replicative Cell Senescence02:15

Replicative Cell Senescence

3.7K
Replicative cell senescence is a property of cells that allows them to divide a finite number of times throughout the organism's lifespan while preventing excessive proliferation. Replicative senescence is associated with the gradual loss of the telomere — short, repetitive DNA sequences found at the end of the chromosomes. Telomeres are bound by a group of proteins to form a protective cap on the ends of chromosomes. Embryonic stem cells express telomerase — an enzyme that adds...
3.7K
The Tumor Microenvironment02:17

The Tumor Microenvironment

6.8K
Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
6.8K
Tumor Immunotherapy01:27

Tumor Immunotherapy

660
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
660
mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

3.9K
The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
3.9K
Psychoneuroimmunology: Diabetes and Cancer01:19

Psychoneuroimmunology: Diabetes and Cancer

62
Chronic stress has been linked to both the onset and progression of serious health conditions, including Type 2 diabetes and cancer. Type 2 diabetes, a widespread chronic illness, is closely associated with obesity and insulin resistance, both of which often worsen under stress. Studies indicate that men experiencing high levels of chronic stress face a 45% higher risk of developing diabetes compared to those with minimal stress. Stress triggers physiological responses that elevate blood...
62

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Synergistic biomineralization of dentin driven by polar amino acids for dentin tubule occlusion.

Journal of oral science·2026
Same author

PACS2 Alleviates Sepsis-Induced Myopathy by Activating ERK-MAPK Signalling Pathway to Suppress ER-Phagy.

Journal of cachexia, sarcopenia and muscle·2026
Same author

KGLAR: Deconvoluting Spatial Transcriptomics Data with Single-cell Transcriptomes through Knowledge-guided NMF and Least Angle Regression.

Interdisciplinary sciences, computational life sciences·2026
Same author

Development and validation of a novel senescence-associated gene signature for prediction of survival and endocrine-disrupting chemicals in bladder cancer.

Discover oncology·2026
Same author

Pan-cancer analysis of TRPV1: a novel immune infiltration-related biomarker for tumor prognosis and immunotherapy response prediction.

BMC cancer·2026
Same author

Enhancing Clinical Competencies Through Peer Role-Play in Oncology Graduate Students: Mixed Methods Study.

JMIR medical education·2025
Same journal

Transplantation tolerance versus immune evasion: Mechanistic divergences and therapeutic frontiers for islet cell replacement.

Cell reports. Medicine·2026
Same journal

Differential T cell clonal dynamics underlie outcomes to frontline chemoimmunotherapy in advanced gastric cancer.

Cell reports. Medicine·2026
Same journal

Targeted DNA triplex-forming oligonucleotide liposome for pulmonary fibrosis gene therapy.

Cell reports. Medicine·2026
Same journal

Metabolomic and lifestyle profiles refine BMI-metabolic phenotypes in older adults.

Cell reports. Medicine·2026
Same journal

Targeting cytokine-like protein FAM3D alleviates atherosclerosis.

Cell reports. Medicine·2026
Same journal

High-dose furmonertinib as first-line treatment for untreated EGFR-mutated advanced NSCLC with central nervous system metastases: A phase 2 trial.

Cell reports. Medicine·2026
See all related articles

Related Experiment Video

Updated: Sep 10, 2025

Evaluation of Tumor-infiltrating Leukocyte Subsets in a Subcutaneous Tumor Model
07:49

Evaluation of Tumor-infiltrating Leukocyte Subsets in a Subcutaneous Tumor Model

Published on: April 13, 2015

20.3K

An age-related decrease in leptin contributes to CD8+ T cell aging in the tumor microenvironment.

Feixiang Wang1, Rujuan Bao2, Shuiyu Xu3

  • 1Institute of Pediatric Infection, Immunity, and Critical Care Medicine, Shanghai Children's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200062, China; Shanghai Institute of Immunology, Department of Immunology and Microbiology, State Key Laboratory of Systems Medicine for Cancer, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.

Cell Reports. Medicine
|August 26, 2025
PubMed
Summary
This summary is machine-generated.

Aging reduces leptin, a hormone that prevents T cell aging in tumors. Lower leptin levels promote senescent CD8+ T cells, weakening the anti-cancer immune response in older adults.

Keywords:
CD8(+) T cellsT cell senescenceagingantitumor immunityleptin

More Related Videos

Tumor Transplantation for Assessing the Dynamics of Tumor-Infiltrating CD8+ T Cells in Mice
07:36

Tumor Transplantation for Assessing the Dynamics of Tumor-Infiltrating CD8+ T Cells in Mice

Published on: June 12, 2021

6.8K
Author Spotlight: A Model to Study the Systemic and Local Dynamics of CD8+ T Cells During LN Metastasis
07:45

Author Spotlight: A Model to Study the Systemic and Local Dynamics of CD8+ T Cells During LN Metastasis

Published on: January 26, 2024

2.1K

Related Experiment Videos

Last Updated: Sep 10, 2025

Evaluation of Tumor-infiltrating Leukocyte Subsets in a Subcutaneous Tumor Model
07:49

Evaluation of Tumor-infiltrating Leukocyte Subsets in a Subcutaneous Tumor Model

Published on: April 13, 2015

20.3K
Tumor Transplantation for Assessing the Dynamics of Tumor-Infiltrating CD8+ T Cells in Mice
07:36

Tumor Transplantation for Assessing the Dynamics of Tumor-Infiltrating CD8+ T Cells in Mice

Published on: June 12, 2021

6.8K
Author Spotlight: A Model to Study the Systemic and Local Dynamics of CD8+ T Cells During LN Metastasis
07:45

Author Spotlight: A Model to Study the Systemic and Local Dynamics of CD8+ T Cells During LN Metastasis

Published on: January 26, 2024

2.1K

Area of Science:

  • Immunology
  • Gerontology
  • Metabolic research

Background:

  • T cell dysfunction increases cancer incidence in the elderly.
  • The mechanisms of T cell aging within the tumor microenvironment are not fully understood.

Purpose of the Study:

  • To investigate the role of adipocyte-derived leptin in age-associated T cell senescence within tumors.
  • To explore the link between metabolic changes and T cell aging in cancer.

Main Methods:

  • Single-cell profiling of human and mouse cancer tissues.
  • Analysis of T cell senescence markers and leptin levels.
  • Correlation analysis between plasma leptin and intratumoral T cell senescence.

Main Results:

  • Intratumoral senescent CD8+ T cells increase with age, impairing anti-tumor immunity.
  • Reduced adipocyte-derived leptin is a key driver of CD8+ T cell aging.
  • Leptin signaling inhibits p38-dependent T cell senescence.
  • Lower plasma leptin correlates with higher T cell senescence in cancer patients.

Conclusions:

  • Age-associated reduction in leptin contributes to T cell senescence in the tumor microenvironment.
  • Metabolic factors, like leptin, play a crucial role in T cell aging.
  • Modulating leptin levels may offer a therapeutic strategy for elderly cancer patients.