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The heart-brain crosstalk in age related cardiovascular and neurodegenerative diseases

Muhammad Ahmad Fahim1, Yao Yao2, Srinivas M Tipparaju1

  • 1Department of Pharmaceutical Sciences, USF Health Taneja College of Pharmacy, University of South Florida, Tampa, FL, 33612, USA.

Fluids and Barriers of the CNS
|August 27, 2025
PubMed

Insights

Aging disrupts heart-brain communication, increasing risks for cardiovascular and neurodegenerative diseases. Understanding this crosstalk is key to developing therapies for age-related conditions affecting both organs.

Area of Science:

  • Gerontology
  • Neuroscience
  • Cardiology

Background:

  • Aging is a significant risk factor for cardiovascular and neurodegenerative diseases.
  • The communication pathway between the heart and brain (heart-brain crosstalk) deteriorates with age.
  • Age-related dysfunction in the heart and brain often occurs concurrently.

Purpose of the Study:

  • To review the evidence linking cardiovascular and neurodegenerative disorders in aging.
  • To explore the mechanisms underlying age-related heart-brain crosstalk.
  • To identify potential therapeutic targets for preserving heart and brain health in older adults.

Main Methods:

  • Literature review of current evidence on heart-brain interactions in aging.
  • Analysis of mechanisms contributing to heart-brain crosstalk.
  • Synthesis of findings to understand age-related disease pathophysiology.

Main Results:

  • Aging impairs bidirectional heart-brain communication.
  • Mechanisms include blood-brain barrier breakdown, vascular dysfunction, nervous system changes, inflammation, and endocrine issues.
  • These factors explain the frequent co-occurrence of heart and brain dysfunction in aging.

Conclusions:

  • Heart-brain crosstalk is crucial in age-related cardiovascular and neurodegenerative diseases.
  • Understanding these links offers insights into disease mechanisms.
  • Targeting these pathways may preserve heart and brain health in the elderly.

Keywords:
AgingBlood-brain barrierNeuroinflammationVascular dysfunction

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