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3D printable PCL-b-P(MMA-co-TMSPMA)/silica hybrids using a PCL RAFT agent.

Athanasios Skandalis1, Haffsah Iqbal1, Gloria Young1

  • 1Department of Materials, Imperial College London, SW7 2AZ, London, UK. julian.r.jones@imperial.ac.uk.

Journal of Materials Chemistry. B
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Summary

This study developed novel silica/poly(ε-caprolactone-methacrylate) hybrid biomaterials for bone regeneration. These hybrids demonstrate promising mechanical properties and biocompatibility for 3D printed scaffolds.

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Area of Science:

  • Biomaterials Science
  • Polymer Chemistry
  • Biomedical Engineering

Background:

  • Inorganic/organic hybrid biomaterials offer combined benefits of bioactive glasses and load-bearing capacity.
  • Controlled polymerization techniques are crucial for designing advanced hybrid structures.

Purpose of the Study:

  • To synthesize and characterize novel silica/poly(ε-caprolactone-methacrylate) hybrid biomaterials.
  • To investigate the effect of composition on mechanical properties for 3D printing applications.
  • To evaluate the potential of these hybrids as scaffolds for bone tissue engineering.

Main Methods:

  • Controlled polymerization of PCL-b-P(MMA-co-TMSPMA) block copolymers using RAFT and ROP techniques.
  • Hybrid material preparation via sol-gel method with TMSPMA for silica-polymer covalent bonding.
  • Mechanical property testing, 3D printing of porous scaffolds, degradation studies, and in vitro biocompatibility assays.

Main Results:

  • Optimal hybrid compositions exhibited yield stress of 39.3-52.9 MPa.
  • 3D printed scaffolds (234-380 μm pores) showed reduced yield strength (5.2-7.4 MPa) but maintained yield strain (~4%).
  • Scaffolds demonstrated ~30% PCL degradation over 180 days and biocompatibility with human bone marrow stem cells.

Conclusions:

  • Silica/PCL-based hybrids are suitable for creating mechanically stable, 3D printable bone scaffolds.
  • The developed materials show potential for bone tissue engineering due to their degradation profile and biocompatibility.