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Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications
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Engineering Metal-Organic Framework-Biopolymer-Based Hydrogels for Therapeutic Delivery.

Talia A Shmool1, Néis Lartigue1,2, Xu Liu3

  • 1Department of Chemical Engineering, Imperial College London, South Kensington Campus, London SW7 2AZ, U.K.

ACS Materials Au
|July 11, 2026
PubMed
Summary

New metal-organic framework (MOF)-biopolymer hydrogels enhance stability and drug delivery. These advanced carriers offer tunable properties for improved therapeutic applications.

Keywords:
advanced characterizationbiopolymersdrug deliveryhydrogelsmetal−organic frameworks

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Area of Science:

  • Materials Science
  • Biomedical Engineering
  • Drug Delivery Systems

Background:

  • Biopolymer hydrogels are promising therapeutic carriers but face limitations in strength, stability, and controlled release.
  • Existing hydrogels struggle with poor rheological strength, physical/thermal stability, and limited swelling.
  • Controlled therapeutic delivery remains a significant challenge for current biopolymer hydrogel systems.

Purpose of the Study:

  • To develop innovative metal-organic framework (MOF)-biopolymer-based hydrogels to overcome limitations of traditional hydrogels.
  • To investigate the impact of integrating ZIF-8 and ZAF MOFs into chitosan/alginate and chitosan/gelatin hydrogels.
  • To evaluate the enhanced physicochemical properties and therapeutic release kinetics of the novel MOF-hydrogels.

Main Methods:

  • Fabrication of MOF-biopolymer hydrogels by incorporating zeolitic imidazole framework-8 (ZIF-8) and zinc adeninate framework (ZAF) into chitosan/alginate (C/A) and chitosan/gelatin (C/G) matrices.
  • Characterization of hydrogel properties including rheological strength, swelling capacity, thermal stability, and immunoglobulin G (IgG) release rates.
  • Analysis of the interactions (ion-dipole, electrostatic, hydrogen bonding) between MOFs and biopolymers to understand their influence on hydrogel performance.

Main Results:

  • MOF-hydrogels exhibited significantly improved rheological strengths, swelling capabilities, and thermostabilities compared to hydrogels without MOFs.
  • MOF-C/A-hydrogels demonstrated superior rheological strengths over MOF-C/G-hydrogels.
  • ZIF-8 hydrogels showed higher rheological strength and IgG release rates but lower thermal stability than ZAF hydrogels, attributed to ZAF's flexibility and steric hindrance.

Conclusions:

  • The integration of MOFs into biopolymer hydrogels effectively enhances their mechanical strength, stability, and swelling properties.
  • Exploiting MOF-biopolymer interactions allows for precise control over therapeutic release rates, balancing swelling and strength.
  • These advanced MOF-biopolymer hydrogels represent a versatile platform for next-generation therapeutic carriers with tunable properties for targeted applications.