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Reduction of Alkenes: Asymmetric Catalytic Hydrogenation02:17

Reduction of Alkenes: Asymmetric Catalytic Hydrogenation

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Catalytic hydrogenation of alkenes is a transition-metal catalyzed reduction of the double bond using molecular hydrogen to give alkanes. The mode of hydrogen addition follows syn stereochemistry.
The metal catalyst used can be either heterogeneous or homogeneous. When hydrogenation of an alkene generates a chiral center, a pair of enantiomeric products is expected to form. However, an enantiomeric excess of one of the products can be facilitated using an enantioselective reaction or an...
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The presence of a catalyst affects the rate of a chemical reaction. A catalyst is a substance that can increase the reaction rate without being consumed during the process. A basic comprehension of a catalysts’ role during chemical reactions can be understood from the concept of reaction mechanisms and energy diagrams.
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The concept of prochirality leads to the nomenclature of the individual faces of a molecule and plays a crucial role in the enantioselective reaction. It is a concept where two or more achiral molecules react to produce chiral products. A typical process is the reaction of an achiral ketone to generate a chiral alcohol. Here, the achiral reactant reacts with an achiral reducing agent, sodium borohydride, to generate an equimolar mixture of the chiral enantiomers of the product. For example, an...
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The rate of acid-catalyzed hydration of alkenes depends on the alkene's structure, as the presence of alkyl substituents at the double bond can significantly influence the rate.
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A significant aspect of hydroboration–oxidation is the regio- and stereochemical outcome of the reaction.
Hydroboration proceeds in a concerted fashion with the attack of borane on the π bond, giving a cyclic four-centered transition state. The –BH2 group is bonded to the less substituted carbon and –H to the more substituted carbon. The concerted nature requires the simultaneous addition of –H and –BH2 across the same face of the alkene giving syn...
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In the presence of organic peroxides, the addition of hydrogen bromide to an alkene yields the isomer that is not predicted by Markovnikov’s rule. For example, the addition of hydrogen bromide to 2-methylpropene in the presence of peroxides gives 1-bromo-2-methylpropane. This addition reaction proceeds via a free radical mechanism, which reverses the regioselectivity. The free radical reaction mechanism involves three stages: initiation, propagation, and termination.
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Correction: Heterogeneous organocatalysis: the proline case.

Gustavo Senra G de Carvalho1, Douglas C Alcântara Pinto1, Robson Corrêa da Silva1

  • 1Universidade Federal Fluminense, Instituto de Química, Departamento de Química Orgânica, Campus do Valonguinho Niterói RJ Brazil senradcarvalho@gmail.com fcsilva@id.uff.br.

RSC Advances
|August 27, 2025
PubMed
Summary
This summary is machine-generated.

This study details corrections to a previously published article, ensuring the accuracy of scientific data and research findings. The corrected article DOI is provided for proper citation and reference.

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Area of Science:

  • Scientific publishing
  • Research integrity
  • Scholarly communication

Context:

  • Correction of a previously published article
  • Ensuring accuracy in scientific literature
  • Maintaining the integrity of research records

Purpose:

  • To provide the correct article DOI
  • To rectify a citation error
  • To facilitate accurate referencing of research

Summary:

  • The article provides a correction notice
  • The correct DOI for the article 10.1039/D5RA02331A is now available
  • This ensures the article is correctly identified and cited

Impact:

  • Improved accuracy in scientific databases
  • Enhanced reliability of research citations
  • Facilitation of correct access to the scientific work