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Updated: Sep 10, 2025
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Microbiota Analysis Using Two-step PCR and Next-generation 16S rRNA Gene Sequencing
Published on: October 15, 2019
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Gut microbiota and tuberculosis
Yanhua Liu1, Ling Yang1,2, Maryam Meskini3,4
1Institute of Tuberculosis, Senior Department of Tuberculosis the Eighth Medical Center of PLA General Hospital Beijing China.
Imeta
|August 27, 2025
Summary
The gut microbiota (GM) significantly influences tuberculosis (TB) progression and treatment response. Understanding this bidirectional relationship is key to developing new diagnostic and therapeutic strategies for TB.
Area of Science:
- Microbiology
- Immunology
- Genomics
Background:
- Tuberculosis (TB), caused by Mycobacterium tuberculosis (MTB), is a major global health issue.
- Gut microbiota (GM) alterations are increasingly linked to TB susceptibility, progression, and drug response.
Purpose of the Study:
- To systematically review current research on the complex relationship between GM and TB.
- To explore GM's potential in TB diagnosis, treatment, and prevention.
Main Methods:
- Systematic review and analysis of existing literature.
- Focus on bidirectional effects, drug interactions, immune response, and technological advancements (multi-omics, AI).
Main Results:
- MTB infection causes GM dysbiosis, impacting host immunity and TB progression.
- GM interactions influence anti-TB drug efficacy.
- Multi-omics and AI are crucial for understanding GM-TB dynamics.
Conclusions:
- GM plays a critical role in TB pathogenesis and treatment.
- Future research should focus on GM's role in vaccine efficacy, prevention, diagnostics, and recurrence.
- Microbiome-based strategies offer promising avenues for TB control.
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