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Mapping Knock-Down Resistance Mutations in Head-Louse Populations in Jazan, Saudi Arabia
1Department of Biological Sciences, Faculty of Science, King Abdulaziz University, Jeddah, Saudi Arabia.
Introduction:
Pediculosis capitis remains a persistent public-health concern. Although pyrethroids are still the first-line treatment, their effectiveness is threatened by knock-down resistance (kdr), which arises from point mutations in the voltage-sensitive sodium channel (VSSC). This study aimed to assess the prevalence of kdr mutations in head lice populations across different regions of Jazan, Saudi Arabia.
Methods:
In this study, 59 head-louse specimens from multiple regions of Jazan were analyzed by PCR amplification and Sanger sequencing of a 908-bp fragment of the VSSC α-subunit gene.
Results:
The T917I mutation showed the highest allele frequency (0.38) and was concentrated in Jazan's southern and eastern border areas.
Discussion:
While overall kdr prevalence in Jazan is low, targeted surveillance is warranted in these regions, where resistance appears to be emerging.
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