Predictive Value of Thyroid Function and FDS Score in Subacute Combined Degeneration

Area of Science:

• Neurology
• Endocrinology
• Clinical Medicine

Background:

• Thyroid dysfunction is increasingly recognized as a factor influencing neurological outcomes.
• The short-term prognosis of stroke patients requires accurate predictive tools for effective management.

Purpose of the Study:

• To investigate the impact of thyroid function on short-term prognosis in patients with stroke.
• To evaluate the predictive value of the Function Disability Scale (FDS) score combined with thyroid function for poor prognosis.

Main Methods:

• Retrospective analysis of 40 stroke patients (SCD) from January 2021 to December 2022.
• Assessment of neurological deficits using FDS at admission and modified Rankin Scale (mRS) at 3 months post-discharge.
• Comparison between normal thyroid function and hypothyroidism groups, with logistic regression and ROC curve analysis for risk factors and predictive performance.

Main Results:

• Hypothyroidism was linked to lower folic acid, higher MCHC, and worse mRS scores.
• Elevated TSH and high admission FDS scores were identified as independent risk factors for poor prognosis (mRS > 2).
• The combination of FDS score and TSH levels showed high predictive accuracy (AUC=0.978), with 100% sensitivity and 91.3% specificity.

Conclusions:

• Elevated TSH levels are associated with worse short-term outcomes in stroke patients.
• The combined use of FDS score and TSH levels significantly enhances prognostic prediction.
• This combination may serve as a valuable clinical tool for risk stratification in stroke patients.