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Generation of Multivirus-specific T Cells to Prevent/treat Viral Infections after Allogeneic Hematopoietic Stem Cell Transplant
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BK polyomavirus genotype IV isolates from virus-specific T-cell therapy recipients

Tiana A Walder1, Heidi L Meeds1, Michael S Grimley2

  • 1Division of Gastroenterology and Hepatology, College of Medicine, University of Cincinnati, Cincinnati, Ohio, USA.

Microbiology Resource Announcements
|August 27, 2025
PubMed

BK polyomavirus (BKPyV) can cause disease in transplant recipients. Virus-specific T-cell (VST) therapy is effective in decreasing virus levels in many individuals. BKPyV genetic variation can impact replication kinetics and immune responses. Here, we present the near full-length BKPyV genome sequences from two VST recipients in which genotype IV was isolated.

Keywords:
BK polyomavirusgenotypetransplantationviral diversityvirus-specific T-cell therapy

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