Related Experiment Video

Updated: Jul 27, 2026

Processing of Primary Brain Tumor Tissue for Stem Cell Assays and Flow Sorting
08:14

Processing of Primary Brain Tumor Tissue for Stem Cell Assays and Flow Sorting

Published on: September 25, 2012

The epidemiology of primary nervous system tumors in children

S Preston-Martin

    Italian Journal of Neurological Sciences
    |December 1, 1985
    PubMed

    Insights

    Childhood brain tumors are more common in boys than girls, with incidence rates varying by geography and race. This study reviews incidence data and potential risk factors for pediatric central nervous system tumors.

    Area of Science:

    • Neuro-oncology
    • Pediatric Epidemiology
    • Cancer Research

    Background:

    • Primary tumors of the brain and nervous system are a significant health concern in children.
    • Understanding the descriptive epidemiology of these tumors is crucial for public health initiatives.
    • Previous studies have explored various aspects, but a comprehensive review of international incidence data for children is warranted.

    Purpose of the Study:

    • To describe the epidemiology of primary brain and nervous system tumors in children aged 0-14 years globally.
    • To analyze incidence rates by sex, geographic area, and race.
    • To compare childhood tumor data with adult findings and review potential risk factors.

    Main Methods:

    • Utilized international incidence data for primary brain and nervous system tumors.
    • Focused on the pediatric population aged 0-14 years.
    • Performed descriptive epidemiological analysis, including calculation of incidence rates and sex ratios.

    Main Results:

    • Median cumulative incidence rates were 0.47 per thousand for boys and 0.39 per thousand for girls.
    • A male:female sex ratio of 1.2 was observed.
    • Significant variations in incidence rates were noted across different geographic areas and racial groups.

    Conclusions:

    • Childhood brain and nervous system tumors exhibit distinct epidemiological patterns, with a higher incidence in boys.
    • Geographic and racial variations suggest potential environmental or genetic influences.
    • Further research into risk factors is essential for developing targeted prevention and intervention strategies.

    More Related Videos

    Endoscopic Third Ventriculostomy and Pineal Biopsy from a Single Entry Point03:13

    Endoscopic Third Ventriculostomy and Pineal Biopsy from a Single Entry Point

    Published on: June 28, 2024

    Establishment of Orthotopic Patient-derived Xenograft Models for Brain Tumors using a Stereotaxic Device07:44

    Establishment of Orthotopic Patient-derived Xenograft Models for Brain Tumors using a Stereotaxic Device

    Published on: May 2, 2025

    Related Concept Videos

    The Retinoblastoma Gene01:20

    The Retinoblastoma Gene

    Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
    The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...
    Disorders of the Nervous Tissue01:28

    Disorders of the Nervous Tissue

    Nervous tissue is a vital component of the human body's communication system, enabling us to perceive and respond to stimuli. However, like all other tissues, it is vulnerable to disorders and diseases that can significantly impact our neurological functioning.
    Homeostatic Imbalances:
    Alzheimer's disease manifests as a gradual decline in memory and cognitive abilities, attributed to the buildup of amyloid plaques and neurofibrillary tangles in the brain.
    Parkinson's disease arises from the...
    Pharmacokinetics in Pediatric Patients: Drug Distribution01:17

    Pharmacokinetics in Pediatric Patients: Drug Distribution

    Drug distribution in the pediatric population exhibits unique challenges and considerations due to the physiological differences between children, particularly neonates and infants, and adults. A crucial aspect of pediatric pharmacology is understanding how these differences impact the pharmacokinetics of various drugs, necessitating age-specific dosing strategies to ensure efficacy and safety.Neonates and infants have a higher total body water content, ~75%–90% of their body weight, compared...
    Pharmacokinetics in Pediatric Patients: Drug Metabolism01:24

    Pharmacokinetics in Pediatric Patients: Drug Metabolism

    In pediatric care, understanding the nuances of hepatic drug metabolism is crucial, as it significantly differs from that of adults. This divergence is primarily due to the developmental stage of drug-metabolizing enzymes, which affects how medications are processed in the body. In neonates, for instance, the activity of Phase I enzymes—critical for the initial breakdown of drugs—is markedly reduced, functioning at just 20–40% of the levels seen in adults. This reduction poses a challenge in...
    Encephalitis l: Introduction01:19

    Encephalitis l: Introduction

    Encephalitis is inflammation of the brain parenchyma, most often due to infections or autoimmune processes. It presents with neuropsychiatric features such as fever, altered mental status, behavioral changes, cognitive dysfunction, seizures, focal deficits, and sometimes autonomic instability. In some cases, the meninges are also involved, resulting in meningoencephalitis.Infectious CausesInfectious encephalitis is most commonly viral but can also result from bacterial, fungal, or parasitic...