Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Advanced microfluidic and 3D cell culture platforms for modeling vascularization in diabetic foot ulcers: A systematic review of translational challenges and perspectives.

PloS one·2026

Same author

Comparison of a novel pen-like electrode and standard patch electrodes for perineal muscle stimulation in women: a pilot study.

Biomedical physics & engineering express·2026

Same author

Geodiamolide A, a Marine Sponge Depsipeptide, Halts Proliferation and Triggers Cell Death in Squamous Cell Carcinoma (A431, NMSC) In Vitro.

International journal of molecular sciences·2026

Same author

Changes on computed tomography in post-acute COVID-19 syndrome: systematic review and meta-analysis.

Radiologia brasileira·2025

Same author

Global warming impacts on lactating mammalian milk: A systematic review.

The Science of the total environment·2025

Same author

Curcumin and Papain-Loaded Liposomal Natural Latex Dressings with Phototherapy: A Synergistic Approach to Diabetic Wound Healing.

Pharmaceuticals (Basel, Switzerland)·2025

Search research articles

Related Experiment Video

Updated: Sep 10, 2025

Construction of a Human Aorta Smooth Muscle Cell Organ-On-A-Chip Model for Recapitulating Biomechanical Strain in the Aortic Wall

Construction of a Human Aorta Smooth Muscle Cell Organ-On-A-Chip Model for Recapitulating Biomechanical Strain in the Aortic Wall

Published on: July 6, 2022

State-of-the-Art Organ-on-Chip Models and Designs for Medical Applications: A Systematic Review.

Gustavo Adolfo Marcelino de Almeida Nunes¹, Ana Karoline Almeida da Silva¹, Rafael Mendes Faria^1,2

¹Postgraduate Programme in Mechatronic Systems, Department of Mechanical Engineering, Campus Darcy Ribeiro, University of Brasilia, Brasilia 70910-900, DF, Brazil.

Biomimetics (Basel, Switzerland)

|August 27, 2025

Summary

Organ-on-a-chip (OoC) devices offer advanced preclinical models for drug discovery and physiological research. This review details OoC designs, enhancing biomimetic capabilities and ethical research practices.

Keywords:

3D bioprinting Organ-on-a-Chip Patient-Specific Models cell microenvironment microfluidics microphysiological systems translational medicine

More Related Videos

Scalable Fabrication of Stretchable, Dual Channel, Microfluidic Organ Chips

Scalable Fabrication of Stretchable, Dual Channel, Microfluidic Organ Chips

Published on: October 20, 2018

Reconstituting Cytoarchitecture and Function of Human Epithelial Tissues on an Open-Top Organ-Chip

Reconstituting Cytoarchitecture and Function of Human Epithelial Tissues on an Open-Top Organ-Chip

Published on: February 17, 2023

Related Experiment Videos

Last Updated: Sep 10, 2025

Construction of a Human Aorta Smooth Muscle Cell Organ-On-A-Chip Model for Recapitulating Biomechanical Strain in the Aortic Wall

Construction of a Human Aorta Smooth Muscle Cell Organ-On-A-Chip Model for Recapitulating Biomechanical Strain in the Aortic Wall

Published on: July 6, 2022

Scalable Fabrication of Stretchable, Dual Channel, Microfluidic Organ Chips

Scalable Fabrication of Stretchable, Dual Channel, Microfluidic Organ Chips

Published on: October 20, 2018

Reconstituting Cytoarchitecture and Function of Human Epithelial Tissues on an Open-Top Organ-Chip

Reconstituting Cytoarchitecture and Function of Human Epithelial Tissues on an Open-Top Organ-Chip

Published on: February 17, 2023

Area of Science:

Biomedical Engineering
Microfluidics
Tissue Engineering

Background:

Organ-on-a-chip (OoC) devices are microphysiological systems that mimic human organ functions.
They offer potential advantages over traditional preclinical models for drug discovery and disease modeling.
Understanding OoC design principles is crucial for developing more accurate and predictive biological models.

Purpose of the Study:

To systematically review and provide a comprehensive overview of microphysiological platform designs.
To analyze the current state of Organ-on-a-chip technology, focusing on design principles.
To identify recent advances and future prospects in Organ-on-a-chip development.

Main Methods:

Systematic review registered in PROSPERO (CRD42022352569).
Adherence to Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines.
Inclusion of studies using human primary or secondary lineage cells.

Main Results:

Screened 3,150 articles after initial retrieval and duplicate removal from major scientific databases.
Included 18 studies in the systematic review after full-text analysis.
Examined OoC design principles including structure, dimensions, cell culturing, and manufacturing techniques, alongside recent advances and future directions.

Conclusions:

Microphysiological devices are valuable tools for drug discovery and understanding human physiology.
OoC technology contributes to more ethical research by reducing animal testing.
Further development in OoC design can lead to more precise and functional biomimetic models.