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Related Concept Videos

Bioplastics01:27

Bioplastics

Bioplastics derived from microbial processes present a sustainable alternative to conventional petroleum-based plastics. Among these, polyhydroxyalkanoates (PHAs), particularly polyhydroxybutyrates (PHBs), have emerged as prominent candidates due to their biodegradability and biocompatibility. These polymers are synthesized by a variety of bacteria, such as Cupriavidus necator and Pseudomonas putida, which naturally accumulate PHAs as intracellular carbon and energy reserves, especially under...

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Hybrid Alginate-Graphene Composites: Biochemical Features and Biomedical Potential.

Marcin H Kudzin1, Anna Kaczmarek1, Zdzisława Mrozińska1

  • 1Łukasiewicz Research Network, Lodz Institute of Technology, 19/27 Marii Sklodowskiej-Curie Str., 90-570 Lodz, Poland.

Marine Drugs
|August 27, 2025
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Summary

Alginate-graphene oxide composites show promise for biomedical applications. These materials exhibit good biocompatibility and do not harm blood or skin cells, suggesting safe use.

Keywords:
DNA damageHs68 cellsPBM cellsactivated partial thromboplastin timealginic acidblood coagulationcalciumcell viabilitycomposite materialpolymer functionalisationprothrombin time

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Area of Science:

  • Biomaterials Science
  • Nanotechnology
  • Biomedical Engineering

Background:

  • Alginate-based materials are promising for biomedical use but face challenges with mechanical strength and biocompatibility.
  • Graphene oxide (GO) incorporation can enhance material properties.
  • Developing robust and biocompatible alginate composites is crucial for advanced biomedical applications.

Purpose of the Study:

  • To fabricate and characterize novel alginate-graphene oxide hybrid composites.
  • To evaluate the haemostatic properties and biocompatibility of these composites.
  • To assess the potential of these materials for blood and skin cell interactions.

Main Methods:

  • Hybrid composites were fabricated using freeze-drying and cross-linked with calcium chloride.
  • Structural and morphological analyses were performed using SEM, EDS, ICP-MS, and BET.
  • Haemostasis was evaluated via activated partial thromboplastin time (aPTT) and prothrombin time (PT) assays.
  • Cytotoxicity and genotoxicity were assessed using peripheral blood mononuclear (PBM) cells and Hs68 fibroblasts.

Main Results:

  • The composites displayed a porous architecture with confirmed calcium incorporation.
  • Graphene oxide and cross-linking influenced surface characteristics and pore parameters.
  • The materials modulated the intrinsic coagulation pathway (aPTT) but not the extrinsic pathway (PT).
  • No cytotoxic or genotoxic effects were observed on PBM cells or Hs68 fibroblasts.

Conclusions:

  • Alginate-graphene oxide composites possess tunable structural properties.
  • These composites demonstrate biocompatibility and safety for blood and skin cells.
  • The developed materials show potential for haemostatic applications and tissue engineering.