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Mannan-Containing Polymers from Hadal Bacterium Psychrobacter pulmonis: Preparation, Structural Analysis,

Mingxing Qi1, Shuqiang Yan1, Yukun Cui2

  • 1College of Food Science and Technology, Shanghai Ocean University, Shanghai 201306, China.

Marine Drugs
|August 27, 2025
PubMed

Insights

Exopolysaccharides from the hadal bacterium Psychrobacter pulmonis enhance immune cell activity and inhibit cancer cell proliferation. These microbial compounds show promise for drug development, particularly for their anti-cancer properties.

Area of Science:

  • Microbiology
  • Biochemistry
  • Immunology
  • Pharmacology

Background:

  • Microbial exopolysaccharides from extreme environments are valuable for drug discovery.
  • Hadal bacteria like Psychrobacter pulmonis are underexplored sources of bioactive compounds.

Purpose of the Study:

  • To isolate and characterize exopolysaccharides from Psychrobacter pulmonis.
  • To evaluate the immunomodulatory and anti-cancer effects of these exopolysaccharides.

Main Methods:

  • Isolation and purification using column chromatography.
  • Structural characterization via FTIR, NMR, and monosaccharide analysis.
  • In vitro assays for macrophage activity and cancer cell proliferation/apoptosis.

Main Results:

  • Four exopolysaccharide fractions (XL-1, XMRS-1, XL-1-D, XMRS-1-D) were purified.
  • All fractions enhanced macrophage proliferation, phagocytosis, and cytokine production (IL-6, TNF-α).
  • Fractions inhibited A549 lung cancer cell proliferation and induced apoptosis via upregulation of pro-apoptotic genes.

Conclusions:

  • Exopolysaccharides from Psychrobacter pulmonis possess significant immunomodulatory and anti-cancer properties.
  • These compounds demonstrate potential for therapeutic applications in drug development.
  • Further research into hadal bacterium-derived exopolysaccharides is warranted.
Keywords:
antitumor effectsextracellular polysaccharidehadal bacteriumimmunological activitymannan-containing polymersstructural characterization

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