A Daily Accumulation Model for Predicting PFOS Residues in Beef Cattle Muscle After Oral Exposure.

Area of Science:

• Environmental Science
• Toxicology
• Animal Science

Background:

• Per- and polyfluoroalkyl substances (PFAS) are widespread environmental contaminants found globally in various matrices, including food sources.
• Diet and drinking water are primary exposure routes for humans and animals to PFAS, with perfluorooctane sulfonate (PFOS) linked to adverse health effects.
• Limited toxicokinetic data exists for PFOS in domestic livestock, hindering accurate human food safety assessments.

Purpose of the Study:

• To develop a simple daily accumulation model (DAM) for predicting perfluorooctane sulfonate (PFOS) residues in edible beef cattle muscle.
• To provide a tool for assessing the accumulation of chemical contaminants in livestock intended for human consumption.

Main Methods:

• A one-compartment toxicokinetic model was developed in a spreadsheet format.
• The model utilized simple calculations to quantify daily PFAS intake and elimination in beef cattle.
• Simulations were conducted for two case studies and a typical beef cattle lifespan.

Main Results:

• The developed DAM reasonably predicted PFOS concentrations in beef cattle muscle under real-world conditions.
• The model facilitated the simulation of PFOS exposure throughout a typical beef cattle lifespan.
• A generic bioaccumulation factor for PFOS in beef cattle was derived using the DAM.

Conclusions:

• The simple daily accumulation model (DAM) is a viable tool for predicting PFOS residues in beef cattle.
• The DAM is adaptable for other PFAS, different livestock species, and various chemical contaminants with long half-lives.
• This model aids in evaluating food safety concerning chemical contaminant accumulation in food-producing animals.