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Updated: Sep 10, 2025

BioMEMS and Cellular Biology: Perspectives and Applications
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Prospects, Advances, and Applications of BioMOF-Based Platforms.

Fangxia Zhao1,2, Xunnan Wan3, Yan Liang3

  • 1The First Clinical Medical College of Guangdong Medical University, Zhanjiang, 524002, Guangdong Province, China.

Topics in Current Chemistry (Cham)
|August 27, 2025
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Bio-metal-organic frameworks (bio-MOFs) offer biocompatibility and biodegradability for advanced applications. This review covers their engineering, drug delivery, bioimaging, and future potential in personalized medicine and environmental solutions.

Keywords:
AdsorptionAntibacterial therapyBio-MOFBioimagingCancer therapyDrug delivery

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Area of Science:

  • Materials Science
  • Biomedical Engineering
  • Nanotechnology

Background:

  • Bio-metal-organic frameworks (bio-MOFs) are advanced hybrid materials with unique biocompatibility and biodegradability.
  • Their host-guest properties enable precise molecular recognition and controlled release.
  • Recent engineering efforts focus on tailoring structure-property relationships for specific applications.

Purpose of the Study:

  • To systematically review recent advancements in bio-MOF engineering.
  • To explore synthesis strategies and structure-property correlations.
  • To discuss the mechanistic applications of bio-MOFs in medicine and environmental science.

Main Methods:

  • Review of recent literature on bio-MOF synthesis and characterization.
  • Analysis of structure-property relationships in tunable pore architectures and surface functionalities.
  • Examination of mechanistic foundations in drug delivery, bioimaging, and therapeutic interventions.

Main Results:

  • Bio-MOFs exhibit tunable pore architectures and surface functionalities.
  • Demonstrated efficacy in targeted drug delivery systems.
  • Successful application in contrast-enhanced bioimaging and multifunctional therapies (anti-inflammatory, antibacterial).

Conclusions:

  • Bio-MOFs represent a promising class of materials for diverse biomedical and environmental applications.
  • Future opportunities lie in personalized medicine and sustainable delivery systems.
  • Cross-disciplinary collaboration is crucial for advancing bio-MOF technology.