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Advances in bone organoids research and future perspectives.
Jingjing Liu1, Jiuzhou Li1, Yasi Chen1
1School of Medical Information Engineering, Gannan Medical University, Ganzhou 341000, People's Republic of China.
Biofabrication
|August 27, 2025
Summary
Bone organoids offer advanced 3D models for studying skeletal diseases and developing treatments. This review details their construction, applications, and future potential in regenerative medicine.
Area of Science:
- Biomedical Engineering
- Regenerative Medicine
- Skeletal Biology
Background:
- Skeletal diseases present a significant global health challenge, requiring advanced research models.
- Traditional 2D cell cultures and animal models have limitations in fully recapitulating bone physiology.
- Organoids are emerging as promising 3D in vitro models for complex biological systems.
Purpose of the Study:
- To review the current state of bone organoid technology.
- To explore methodologies for bone organoid construction and their applications.
- To identify challenges and propose future directions for bone organoid research.
Main Methods:
- Review of existing literature on bone organoid development and applications.
- Analysis of structural characteristics of natural bone.
- Discussion of various bone organoid construction techniques.
Main Results:
- Bone organoids show potential in disease modeling, drug screening, and regenerative medicine.
- Significant challenges remain in enhancing bone organoid functionality and biomimetic properties.
- The review provides theoretical insights and technical guidance for the field.
Conclusions:
- Bone organoids represent a promising frontier in bone tissue engineering.
- Further research is needed to overcome current limitations and improve bone organoid technology.
- This review aims to accelerate the development of advanced bone organoids for clinical applications.
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