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Related Concept Videos

Cardiomyopathy II: Dilated Cardiomyopathy01:30

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Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...
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Restrictive cardiomyopathy (RCM) is a rare heart muscle disease characterized by impaired ventricular filling due to stiffened ventricular walls, leading to significant diastolic dysfunction.EtiologyRestrictive cardiomyopathy can arise from both inherited and acquired diseases, many of which are systemic. It is categorized into four main types: infiltrative, storage, non-infiltrative, and endomyocardial diseases.Infiltrative diseases, such as amyloidosis, lead to RCM by depositing amyloid...
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Heart failure refers to a clinical syndrome caused by structural or functional cardiac disorders that prevent the heart from pumping an adequate amount of blood to meet the body's metabolic needs. This condition often arises from myocardial infarction or ischemia, leading to decreased cardiac output, reduced tissue perfusion, impaired gas exchange, fluid volume imbalance, and decreased functional ability.Heart failure can result from disruptions in the mechanisms that regulate cardiac output...
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Heart failure (HF) is a progressive syndrome involving ventricles that leads to inadequate cardiac output. It can be classified based on location and output or ejection fraction. Ejection fraction (EF) is an essential measurement in the diagnosis and surveillance of HF. Reduced EF corresponds to systolic heart failure (HFrEF). However, HF with preserved ejection fraction (HFpEF) is becoming increasingly prevalent. Also known as diastolic HF, this form of HF is related to aging. The...
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Cardiomyopathy, or CMP, is a group of diseases affecting the myocardial structure, impairing its ability to pump blood effectively. This condition can lead to arrhythmias, heart failure, or sudden cardiac death.Cardiomyopathies are classified into primary and secondary categories:Primary Cardiomyopathy refers to conditions involving only the heart muscle that are often idiopathic (of unknown cause) or genetic. They primarily affect the myocardium without the involvement of other systemic...
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Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
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Related Experiment Video

Updated: Sep 10, 2025

Assessment of Sarcoplasmic Reticulum Calcium Reserve and Intracellular Diastolic Calcium Removal in Isolated Ventricular Cardiomyocytes
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Cardiac TRPM7 Causes Diabetic Heart Failure With Preserved Ejection Fraction.

Man Liu1, Hong Liu1, Gyeoung-Jin Kang1

  • 1Cardiovascular Division, Department of Medicine, Lillehei Heart Institute, University of Minnesota-Twin Cities, Minneapolis, Minnesota, USA.

JACC. Basic to Translational Science
|August 27, 2025
PubMed
Summary

Hypomagnesemia causes diabetic heart failure. Inhibiting the TRPM7 kinase, upregulated in this condition, may treat heart failure with preserved ejection fraction by reducing oxidative stress and mitochondrial dysfunction.

Keywords:
heart failure with preserved ejection fractionkinasemagnesiummitochondriaoxidative stress

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Area of Science:

  • Biochemistry
  • Cardiology
  • Molecular Biology

Background:

  • Hypomagnesemia and oxidative stress contribute to diabetic cardiac diastolic dysfunction and heart failure with preserved ejection fraction.
  • Transient receptor potential cation channel subfamily M 7 (TRPM7), a magnesium transporter, is upregulated in hypomagnesemia.

Purpose of the Study:

  • To investigate the role of TRPM7 in diabetic heart failure with preserved ejection fraction.
  • To explore TRPM7 kinase as a therapeutic target.

Main Methods:

  • Utilized a mouse model of diabetes mellitus.
  • Assessed TRPM7 expression and activity in cardiac tissue.
  • Examined the impact of TRPM7 kinase on mitochondrial function and oxidative stress.

Main Results:

  • Diabetic mice exhibited hypomagnesemia and increased cardiac TRPM7 expression.
  • TRPM7 kinase activity was linked to mitochondrial dysfunction and cardiac diastolic dysfunction.
  • TRPM7 kinase upregulated mitochondrial Fgr, leading to complex II dysfunction and reactive oxygen species overproduction.

Conclusions:

  • TRPM7 kinase plays a critical role in the pathogenesis of diabetic heart failure with preserved ejection fraction.
  • Inhibition of TRPM7 kinase is a potential therapeutic strategy for this condition.