Related Experiment Video
Updated: Sep 10, 2025

An Adoptive Transfer Model of Rheumatoid Arthritis in Mice
Published on: June 6, 2025
Periarticular Other Iatrogenic Immunodeficiency-associated Lymphoproliferative Disorder Mimicking Knee Synovitis in a
Hikaru Hirose1, Tomoaki Higuchi1,2, Yuki Ichimura1
1Department of Rheumatology, Tokyo Women's Medical University School of Medicine, Japan.
Abstract:
Other iatrogenic immunodeficiency-associated lymphoproliferative disorders (OIIA-LPDs) develop in patients with rheumatoid arthritis (RA) during treatment with disease-modifying antirheumatic drugs (DMARDs). Periarticular OIIA-LPDs are rare and poorly understood. An 81-year-old woman with RA presented with knee swelling, a fever, and weight loss. Imaging studies revealed bone erosion and a 18F-fluorodeoxyglucose uptake around the knees. A histopathological analysis was consistent with diffuse large B-cell lymphoma, confirming the diagnosis of OIIA-LPD. Discontinuation of DMARDs resolved the knee swelling and prevented further bone erosion. This report highlights the importance of considering OIIA-LPDs in patients with RA, atypical joint swelling, and systemic symptoms.
More Related Videos
12:23Flow Cytometry Analysis of Immune Cell Subsets within the Murine Spleen, Bone Marrow, Lymph Nodes and Synovial Tissue in an Osteoarthritis Model
Published on: April 24, 2020
08:43Adoptive Immunotherapy of iNKT Cells in Glucose-6-Phosphate Isomerase G6PI-Induced RA Mice
Published on: January 31, 2020
Related Concept Videos
T Cell Types and Functions
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
Rheumatic Heart Disease I: Introduction
Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies
Immunodeficiency Diseases
There are three main causes of immunodeficiency...
The JAK-STAT Signaling Pathway
Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents