Related Experiment Video
Updated: Sep 10, 2025

Intranasal Administration of Recombinant Influenza Vaccines in Chimeric Mouse Models to Study Mucosal Immunity
Published on: June 25, 2015
Synthetic biology-inspired development of live attenuated influenza vaccines
Qisi Zhang1, Jiahui Cheng1, Jihuan Hou1
1State Key Laboratory of Quantitative Synthetic biology, Shenzhen Institute of Synthetic biology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, 518055, Shenzhen, China.
Abstract:
Live attenuated influenza vaccines (LAIVs) provide robust, cross-protective immunity but have traditionally been developed empirically and are associated with safety concerns. Recent advances in rational design enable precise genetic modifications to enhance safety and immunogenicity. This review highlights key molecular strategies advancing next-generation LAIV development and their potential to accelerate the production of safer, more effective vaccines against seasonal and pandemic influenza.
Related Concept Videos
Synthetic Biology
Golden rice
Golden rice is a genetically modified...
Microorganisms in Medicine and Therapeutics

