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Related Experiment Video

Updated: Jun 15, 2026

Multiplexed Fluorescent Immunohistochemical Staining of Four Endometrial Immune Cell Types in Recurrent Miscarriage

Multiplexed Fluorescent Immunohistochemical Staining of Four Endometrial Immune Cell Types in Recurrent Miscarriage

Published on: August 4, 2021

Molecular Imaging in Endometrial Cancer: A Narrative Review.

Ana María García-Vicente¹, María Pilar Perlaza-Jiménez², Stefanía Aida Guzmán-Ortiz¹

¹Nuclear Medicine Department, University Hospital of Toledo, 45007 Toledo, Spain.

|August 28, 2025

Summary

Molecular imaging, including [18F]FDG-PET/CT and PET/MRI, significantly improves endometrial cancer staging and personalized treatment planning. Further research is needed to confirm its clinical efficacy.

Keywords:

[18F]FDG-PET/CT [18F]FDG-PET/MRI endometrial cancer prognosis progression radiomics response staging

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Published on: October 13, 2023

Area of Science:

Oncology
Radiology
Medical Imaging

Background:

Endometrial cancer (EC) is a prevalent gynecological malignancy with complex characteristics.
Advances in molecular imaging, specifically [18F]FDG-PET/CT and PET/MRI, are transforming EC management.

Purpose of the Study:

To review the current evidence on the role of [18F]FDG-PET/CT and PET/MRI in endometrial cancer diagnosis, staging, treatment monitoring, and prognosis.
To discuss the clinical relevance and prognostic implications of molecular imaging in EC.

Main Methods:

A narrative review of current literature on [18F]FDG-PET/CT and PET/MRI in endometrial cancer.
Focus on diagnostic performance, clinical utility, and prognostic value throughout the treatment pathway.

Main Results:

[18F]FDG-PET/CT excels at detecting metastases; PET/MRI enhances T and N staging accuracy.
[18F]FDG-PET/CT identifies early treatment response and differentiates tumor from post-treatment changes.
Radiomics and machine learning show promise for prognostic stratification and personalized treatment planning.

Conclusions:

Molecular imaging improves TNM staging accuracy in endometrial cancer.
Integrating molecular imaging biomarkers can enhance personalized decision-making for EC patients.
Prospective studies are required to validate the efficacy of these imaging techniques.