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Assessing Whole-Body Lipid-Handling Capacity in Mice
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Circulating Lipid Profiles Indicate Incomplete Metabolic Recovery After Weight Loss, Suggesting the Need for
Alina-Iuliana Onoiu1, Vicente Cambra-Cortés1, Andrea Jiménez-Franco1
1Unitat de Recerca Biomèdica, Hospital Universitari de Sant Joan, Institut d'Investigació Sanitària Pere Virgili, Universitat Rovira i Virgili, Av. Dr. Josep Laporte 2, 43204 Reus, Spain.
Biomolecules
|August 28, 2025
Summary
Lipidomics reveals how severe obesity disrupts lipid balance. Weight loss improves but doesn't fully normalize lipid profiles, with specific lipids indicating metabolic recovery and guiding personalized obesity treatment.
Area of Science:
- Metabolomics
- Biochemistry
- Obesity Medicine
Background:
- Long-term effects of weight loss on lipid balance in severe obesity remain unclear.
- Identifying predictive biomarkers for obesity treatment is crucial.
Purpose of the Study:
- To evaluate a non-invasive lipidomic approach for identifying biomarkers.
- To predict patient response to therapies before and after weight loss.
Main Methods:
- Mass spectrometry analysis of 275 lipid species.
- Comparison of non-obese controls, severely obese patients, and post-bariatric surgery patients.
Main Results:
- Severe obesity disrupts lipid pathways, causing lipotoxicity, inflammation, and mitochondrial stress.
- Weight loss partially normalized lipid profiles; outcomes varied with baseline liver health and genetics.
- Specific lipid classes (sterols, glycerophospholipids, sphingolipids) indicate metabolic recovery.
Conclusions:
- Lipidomics can personalize obesity treatment and follow-up strategies.
- Biomarkers can identify patients needing further interventions post-surgery.
- Understanding lipid alterations is key to managing severe obesity.
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