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Post-Radiotherapy Changes in Circulating Dodecanoic Acid Identify Metabolic Phenotypes Associated with Recurrence in
Andrea Jiménez-Franco1,2, Vicente Cambra-Cortés1, Raquel García-Pablo2
1Unitat de Recerca Biomèdica, Hospital Universitari de Sant Joan, Institut d'Investigació Sanitària Pere Virgili, Universitat Rovira i Virgili, Av. Dr. Josep Laporte 2, 43204 Reus, Spain.
Biomolecules
|March 28, 2026
Summary
Circulating dodecanoic acid shows potential as a breast cancer prognostic biomarker. An increase after radiotherapy is linked to a lower risk of progression, suggesting new therapeutic strategies.
Area of Science:
- Oncology
- Metabolomics
- Biochemistry
Background:
- Accurate breast cancer (BC) prognosis requires biomarkers reflecting tumor biology and systemic metabolism.
- Personalized treatment strategies depend on reliable prognostic indicators.
Purpose of the Study:
- To investigate circulating dodecanoic acid as a prognostic biomarker in breast cancer patients undergoing radiotherapy (RT).
- To assess the association between dodecanoic acid levels and progression-free survival (PFS) and overall survival (OS).
Main Methods:
- Analysis of circulating dodecanoic acid in 229 breast cancer patients before and after RT.
- Classification of patients into Increase Phenotype (IP) and Decrease Phenotype (DP) based on dodecanoic acid changes.
- Correlation of dodecanoic acid levels with paraoxonase-1 activity and survival outcomes over six years.
Main Results:
- Dodecanoic acid levels were lower in tumors compared to peritumoral samples.
- The Increase Phenotype (IP) showed lower baseline dodecanoic acid with a post-RT rise, associated with higher paraoxonase-1 activity.
- Patients in the IP group had significantly lower risk of progression compared to the Decrease Phenotype (DP) group; no significant difference in OS was observed.
Conclusions:
- Circulating dodecanoic acid exhibits potential as a prognostic biomarker for breast cancer progression.
- Post-RT increases in dodecanoic acid correlate with improved progression-free survival.
- Modulating fatty acid metabolism presents a potential therapeutic avenue for breast cancer.
