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Zinc Glycinate Alleviates Necrotic Enteritis Infection in Broiler Chickens.

Theros T Ng1, Brandi A Sparling1, Ramesh K Selvaraj2

  • 1College of Veterinary Medicine, Western University of Health Sciences, Pomona, CA 91766, USA.

Animals : an Open Access Journal From MDPI
|August 28, 2025
PubMed
Summary

Zinc glycinate (ZG) supplementation improved chicken growth and reduced necrotic enteritis (NE) severity. Optimal ZG levels in poultry feed enhance bird health and reduce mortality.

Keywords:
chickennecrotic enteritiszinc

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Area of Science:

  • Poultry nutrition and immunology
  • Animal pathology and disease control
  • Gastrointestinal health in livestock

Background:

  • Necrotic enteritis (NE) poses a significant threat to poultry health and economic viability.
  • Understanding the role of specific nutrients like zinc in mitigating NE is crucial.
  • Zinc glycinate (ZG) is a potential dietary supplement for improving chicken health.

Purpose of the Study:

  • To evaluate the efficacy of zinc glycinate (ZG) in preventing and treating necrotic enteritis (NE) in chickens.
  • To determine optimal ZG supplementation levels for improving growth performance and reducing NE-related pathology.
  • To investigate the in vitro effects of zinc on intestinal cell viability against Clostridium perfringens.

Main Methods:

  • Two in vivo experiments with broiler chickens supplemented with varying ZG doses (40-160 mg/kg).
  • One in vitro experiment assessing zinc's effect on HD-11 intestinal cells challenged with Clostridium perfringens.
  • Measurements included body weight gain (BWG), feed conversion ratio (FCR), lesion scores, mortality, and immune gene expression (IFN-γ, SOD1).

Main Results:

  • ZG supplementation at 120 mg/kg significantly improved BWG and reduced NE lesions.
  • Lower mortality was observed with ZG at 80 mg/kg and 120 mg/kg.
  • In vitro, zinc enhanced intestinal cell viability and reduced cytotoxicity under C. perfringens challenge.
  • ZG modulated immune responses, increasing IFN-γ and decreasing Zn/Cu SOD1 expression.

Conclusions:

  • Zinc glycinate (ZG) is effective in mitigating necrotic enteritis in chickens.
  • A dietary ZG level of 120 mg/kg is recommended for optimal performance and disease control in poultry.
  • Further research into zinc's immunomodulatory effects in poultry is warranted.