Association Between Oxidative-Inflammation Biomarkers and Incident Chronic Kidney Disease in People with High...

Area of Science:

• Nephrology
• Cardiovascular Disease
• Metabolic Syndrome
• Biomarkers

Background:

• Overweight/obesity and metabolic syndrome are associated with increased risk of chronic kidney disease (CKD).
• Oxidative stress and inflammation are implicated in the pathogenesis of CKD.
• Predictive biomarkers for early CKD detection in at-risk populations are needed.

Purpose of the Study:

• To evaluate the predictive value of oxidative-inflammatory biomarkers for incident CKD.
• To assess these biomarkers in a cohort of individuals with overweight/obesity and metabolic syndrome.
• To determine the association between an inflammatory-oxidative stress score and CKD incidence.

Main Methods:

• Prospective nested case-control study with 117 CKD incident cases and 117 matched controls.
• Measurements included serum creatinine, cystatin C, urine albumin-to-creatinine ratio, and various inflammatory/oxidative stress biomarkers (e.g., MDA, TNFα, IL-6).
• Estimated Glomerular Filtration Rate (eGFR) and an inflammatory-oxidative stress score were calculated.

Main Results:

• Elevated levels of interleukin-6 (IL-6) and tumor necrosis factor alpha (TNFα) were significantly associated with increased odds of incident CKD.
• The inflammatory-oxidative stress score was positively correlated with CKD incidence.
• Urine albumin-to-creatinine ratio (UACR) showed positive correlations with pro-inflammatory markers.

Conclusions:

• Inflammatory and oxidative stress biomarkers are significant predictors of CKD incidence in individuals with overweight/obesity and metabolic syndrome.
• The findings highlight the importance of identifying early signs of inflammation for CKD prevention strategies.
• Targeting inflammation may be a key therapeutic approach for reducing CKD risk in high-cardiovascular-risk populations.