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Cyclodextrin-Based Delivery Systems for Flavonoids: Mechanisms, Advances, Formulation, and Application Opportunities.
Ferenc Fenyvesi1, Ágnes Klusóczki2, Ágnes Rusznyák1
1Department of Molecular and Nanopharmaceutics, Faculty of Pharmacy, University of Debrecen, H-4002 Debrecen, Hungary.
Antioxidants (Basel, Switzerland)
|August 28, 2025
Summary
Cyclodextrin complexation enhances flavonoid solubility and antioxidant activity, overcoming pharmacokinetic limitations. Nanotechnology further improves delivery for therapeutic applications.
Area of Science:
- Pharmacology and Drug Delivery
- Natural Product Chemistry
Background:
- Flavonoids possess significant antioxidant properties valuable for preventive and therapeutic research.
- Poor water solubility and low bioavailability limit the clinical application of flavonoids.
- Cyclodextrin-based systems offer a promising solution to enhance flavonoid pharmacokinetics.
Purpose of the Study:
- To review the role of cyclodextrin-based carriers in formulating flavonoids.
- To explore the structural characteristics and complexation mechanisms of flavonoid-cyclodextrin complexes.
- To highlight the potential of nanotechnological formulations for enhanced flavonoid delivery.
Main Methods:
- Review of scientific literature on flavonoid-cyclodextrin interactions.
- Analysis of structural features and complexation mechanisms.
- Examination of the impact of complexation on solubility, stability, and biological activity.
- Discussion of nanotechnological approaches like liposomes, nanofibers, and nanosponges.
Main Results:
- Cyclodextrins form stable, water-soluble inclusion complexes with flavonoids.
- Complexation significantly improves flavonoid solubility, chemical stability, and antioxidant activity.
- Nanotechnological formulations enhance targeted delivery and therapeutic efficacy of flavonoids.
Conclusions:
- Cyclodextrin-based carriers are effective in overcoming pharmacokinetic limitations of flavonoids.
- Nanotechnology-enabled formulations offer advanced strategies for flavonoid delivery.
- These systems hold substantial future potential in therapeutics and functional product development.
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