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Updated: Sep 10, 2025
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Rapid Detection of Neurodevelopmental Phenotypes in Human Neural Precursor Cells NPCs
Published on: March 2, 2018
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Non-Coding RNAs in Neurodevelopmental Disorders-From Diagnostic Biomarkers to Therapeutic Targets: A Systematic
Katerina Karaivazoglou1, Christos Triantos2, Ioanna Aggeletopoulou2
1Department of Psychiatry, University of Patras, 26504 Patras, Greece.
Biomedicines
|August 28, 2025
Summary
Non-coding RNAs (ncRNAs) are key regulators in neurodevelopmental disorders like autism spectrum disorder (ASD) and attention-deficit/hyperactivity disorder (ADHD). Research shows ncRNAs can serve as diagnostic biomarkers and potential therapeutic targets.
Area of Science:
- Neuroscience
- Genetics
- Epigenetics
Background:
- Neurodevelopmental disorders (NDDs) like ASD and ADHD involve complex genetic, environmental, and epigenetic factors.
- Non-coding RNAs (ncRNAs), including miRNAs, lncRNAs, and piRNAs, are crucial epigenetic regulators of neurodevelopment.
- ncRNAs influence gene expression, impacting neuronal differentiation, synaptogenesis, and plasticity.
Purpose of the Study:
- To systematically review recent findings on ncRNAs in NDDs, focusing on the post-COVID-19 era.
- To examine the role of ncRNAs in the pathogenesis, diagnosis, and treatment of NDDs.
- To synthesize current knowledge on ncRNA expression, function, and clinical relevance.
Main Methods:
- Comprehensive literature search for studies on ncRNAs in NDDs.
- Inclusion of human and animal models.
- Focus on expression profiles, functional roles, and clinical applications.
Main Results:
- Differential expression of various ncRNAs observed in individuals with ASD and ADHD.
- Specific miRNAs and lncRNAs show potential as sensitive and specific diagnostic biomarkers.
- ncRNAs actively contribute to NDD pathogenesis by modulating neuronal gene networks.
Conclusions:
- Emerging data suggest exogenous ncRNA administration may reverse NDD phenotypes, indicating therapeutic potential.
- Findings expand understanding of neurodevelopmental regulation.
- Opens new avenues for personalized diagnostics and targeted interventions in neuropsychiatry.
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