Experimental Study of Two-Bite Test Parameters for Effective Drug Release from Chewing Gum Using a Novel...

Area of Science:

• Dental Science
• Food Science
• Pharmaceutical Sciences

Background:

• Masticatory apparatus with artificial oral environments are relevant to multiple scientific fields.
• Existing systems do not accurately mimic human chewing and oral conditions.
• This study addresses the need for advanced simulation of oral conditions.

Purpose of the Study:

• To investigate the role of dental morphology and form-function relationships in drug release from medicated chewing gum (MCG).
• To compare chewing efficiency using a novel humanoid chewing robot and a bionics product lifecycle management (PLM) framework.
• To evaluate two-bite test parameters for effective drug release.

Main Methods:

• Development of a novel, bio-engineered two-bite testbed with compression and torsion capabilities.
• Utilizing a humanoid chewing robot and a bionics PLM framework with reverse biomimetics.
• Conducting two-bite tests to assess MCG mechanical properties and drug release.

Main Results:

• Experimental studies established relationships between biting force, crushing/shearing, and chewing efficiency.
• Mechanochemistry and power stroke were analyzed for disrupting bonds and releasing active pharmaceutical ingredients (APIs).
• The influence of jaw physiology, dental morphology, Bennett angle (BA), and Frankfort-mandibular plane angle (FMA) on test parameters was discussed.

Conclusions:

• The study provides insights into optimizing drug release from MCGs through biomechanical analysis.
• The developed humanoid chewing robot and testbed offer a platform for future research.
• Findings have implications for dental science, food science, and pharmaceutical development.