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Updated: Sep 10, 2025

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Real-time fMRI Biofeedback Targeting the Orbitofrontal Cortex for Contamination Anxiety
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Biofeedback in Pediatric, Adolescent, and Young Adult Cancer Care: A Systematic Review
Marie Barnett1, Shari A Langer2, Konstantina Matsoukas1
1Memorial Sloan Kettering Cancer Center, Department of Psychiatry, New York, NY 10065, USA.
Children (Basel, Switzerland)
|August 28, 2025
Summary
Biofeedback shows promise for managing pediatric and adolescent/young adult (AYA) cancer symptoms like pain and anxiety. However, limited high-quality research necessitates more rigorous studies to confirm its effectiveness in this population.
Area of Science:
- Oncology
- Rehabilitation Medicine
- Psychology
Background:
- Biofeedback interventions are widely used in pediatric and adult healthcare.
- Evidence for biofeedback efficacy in pediatric and adolescent/young adult (AYA) cancer patients is scarce.
- This systematic review addresses the limited research on biofeedback in pediatric and AYA oncology.
Purpose of the Study:
- To systematically review and synthesize existing research on biofeedback in pediatric and AYA oncology.
- To identify research gaps in biofeedback for this specific patient group.
- To provide recommendations for future research and clinical applications.
Main Methods:
- Systematic literature search across six major bibliographic databases.
- Inclusion criteria: studies on pediatric/AYA oncology patients (0-39 years) receiving biofeedback.
- Methodological quality and risk of bias assessed using the Cochrane Risk of Bias Tool.
Main Results:
- Only 8 out of 1013 screened studies met inclusion criteria (<1%).
- Preliminary findings suggest biofeedback may help manage pain, anxiety, and fatigue in pediatric/AYA cancer patients.
- Included studies exhibited low methodological quality (small samples, no control groups, inconsistencies).
Conclusions:
- Biofeedback is a potentially feasible and effective intervention for pediatric/AYA oncology patients.
- There is a critical need for well-designed, rigorous studies to validate biofeedback's effectiveness.
- Evidence-based practice recommendations require further high-quality research in this field.
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