Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Aortic Stenosis Hyalectan Remodeling Revealed by Proteomics and Glycoproteomics.

Arteriosclerosis, thrombosis, and vascular biology·2026
Same author

Entrepreneurial calling and psychological wellbeing: a qualitative study of a dynamic and regulated work experience.

Frontiers in psychology·2026
Same author

CRT upgrade improves frailty status in patients with HFrEF and RV pacing-a post hoc analysis of the BUDAPEST-CRT trial.

GeroScience·2026
Same author

Impact of Breast Augmentation, Reduction, and Nipple Repair on Breastfeeding Success: A Systematic Review and Meta-analysis.

Aesthetic surgery journal·2026
Same author

Depressive symptoms hopelessness self-efficacy and COVID-19-related stressors among pregnant women in Hungary across two pandemic waves.

Scientific reports·2026
Same author

Knockout of PARP2 in T cells leads to spontaneous colitis with distinct segmental characteristics in PARP1-deficient mice.

Frontiers in immunology·2026

Related Experiment Video

Updated: Sep 10, 2025

A Rat Model of Middle Cerebral Artery Occlusion/Reperfusion Without Damaging the Anatomical Structure of Cerebral Vessels
06:10

A Rat Model of Middle Cerebral Artery Occlusion/Reperfusion Without Damaging the Anatomical Structure of Cerebral Vessels

Published on: May 17, 2024

666

Cerebral Resistance Artery Histological Remodeling After Training-Sex Differences.

Tobias Hainzl1,2, György L Nádasy3, Emese Róza Márka4

  • 1Doctoral School, Semmelweis University, 1091 Budapest, Hungary.

Life (Basel, Switzerland)
|August 28, 2025
PubMed
Summary

Chronic exercise enhances brain artery elasticity in both sexes. Female rats showed a more pronounced increase in vascular elasticity, suggesting sex-specific benefits of exercise on brain blood vessels.

Keywords:
cerebral vesselscolorimetryexercise trainingmorphological changessex differences

More Related Videos

Sex Stratified Neuronal Cultures to Study Ischemic Cell Death Pathways
10:44

Sex Stratified Neuronal Cultures to Study Ischemic Cell Death Pathways

Published on: December 9, 2013

12.1K
Ex Vivo Pressurized Hippocampal Capillary-Parenchymal Arteriole Preparation for Functional Study
09:15

Ex Vivo Pressurized Hippocampal Capillary-Parenchymal Arteriole Preparation for Functional Study

Published on: December 18, 2019

7.0K

Related Experiment Videos

Last Updated: Sep 10, 2025

A Rat Model of Middle Cerebral Artery Occlusion/Reperfusion Without Damaging the Anatomical Structure of Cerebral Vessels
06:10

A Rat Model of Middle Cerebral Artery Occlusion/Reperfusion Without Damaging the Anatomical Structure of Cerebral Vessels

Published on: May 17, 2024

666
Sex Stratified Neuronal Cultures to Study Ischemic Cell Death Pathways
10:44

Sex Stratified Neuronal Cultures to Study Ischemic Cell Death Pathways

Published on: December 9, 2013

12.1K
Ex Vivo Pressurized Hippocampal Capillary-Parenchymal Arteriole Preparation for Functional Study
09:15

Ex Vivo Pressurized Hippocampal Capillary-Parenchymal Arteriole Preparation for Functional Study

Published on: December 18, 2019

7.0K

Area of Science:

  • Neuroscience
  • Cardiovascular Physiology
  • Exercise Science

Background:

  • Chronic exercise is associated with improved cognitive function and brain health.
  • Cerebral resistance artery morphology plays a crucial role in regulating brain blood flow.
  • Potential sex differences in exercise-induced vascular adaptations require further investigation.

Purpose of the Study:

  • To investigate the effects of chronic exercise on cerebral resistance artery morphology.
  • To identify potential sex differences in exercise-induced changes in brain vasculature.

Main Methods:

  • Wistar rats (male and female) were subjected to a 12-week swimming program or remained sedentary.
  • Histological examination of intracerebral and pial arterioles was performed using smooth muscle actin (SMA-DAB) and elastica (resorcin-fuchsin) staining.
  • Quantitative colorimetric analysis was used to assess elastic and smooth muscle fiber density.

Main Results:

  • Exercise increased elastic fiber density in both pial and intracerebral arterioles in both male and female rats compared to sedentary controls.
  • Female exercising rats exhibited higher elastic fiber density in pial arterioles compared to male exercising rats.
  • Smooth muscle density was higher in male sedentary rats' pial arterioles, while exercise increased smooth muscle density in male intracerebral arterioles.

Conclusions:

  • Chronic exercise enhances vascular elasticity in cerebral resistance arteries in both sexes.
  • The augmentation of vascular elasticity due to exercise is more pronounced in female rats.
  • These findings highlight sex-specific adaptations in brain vasculature in response to exercise training.