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Ibuprofen-menthol eutectic systems were developed to improve drug delivery. Some formulations demonstrated reduced toxicity in specific cell lines, indicating potential for safer pharmaceutical applications.

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Area of Science:

  • Pharmaceutical Science
  • Materials Science

Background:

  • Eutectic systems are gaining traction in pharmaceutical research for enhanced drug formulation and delivery.
  • Active pharmaceutical ingredients (APIs) often require innovative delivery methods to improve efficacy.

Purpose of the Study:

  • To prepare and characterize therapeutic eutectic systems (THEESs) using ibuprofen and menthol.
  • To evaluate the physicochemical, rheological, and cytotoxic properties of these novel eutectic systems.

Main Methods:

  • Preparation of ibuprofen-menthol eutectic systems at varying molar ratios.
  • Assessment of physicochemical properties (density, refractive index, etc.) and rheological behavior.
  • Cytotoxicity evaluation using HaCaT and HepG2 cell lines.

Main Results:

  • All prepared systems resulted in clear, viscous, monophasic liquids.
  • Physicochemical properties exhibited temperature-dependent inverse relationships. Viscosity followed the Vogel-Fulcher-Tammann equation, indicating non-Newtonian behavior.
  • Cytotoxicity varied; Ibu-M3 showed reduced toxicity in HaCaT and HepG2 cells compared to pure compounds, while other ratios displayed differential toxicity.

Conclusions:

  • Ibuprofen-menthol eutectic systems possess favorable physicochemical and rheological properties for pharmaceutical processing.
  • Specific eutectic compositions demonstrate potential for improved biocompatibility, suggesting their utility in developing safer drug formulations.