Deep Eutectic Solvent Systems as Media for the Selective Extraction of Anti-Inflammatory Bioactive Agents.

Area of Science:

• Green Chemistry
• Natural Product Chemistry
• Biotechnology

Background:

• Bioactive compounds (BCs) offer health benefits beyond nutrition but require efficient extraction.
• Extraction of anti-inflammatory BCs is crucial for their therapeutic application.
• Deep eutectic systems (DESs) are emerging as promising extraction media.

Purpose of the Study:

• To review the extraction of anti-inflammatory bioactive compounds using deep eutectic systems (DESs).
• To categorize DES extraction media and analyze factors influencing extraction yields.
• To highlight the advantages and limitations of DESs for sustainable bioactive compound extraction.

Main Methods:

• Literature review of studies employing DESs for anti-inflammatory bioactive compound extraction.
• Categorization of DESs into choline chloride-based and natural product-based systems.
• Analysis of extraction yields based on DES composition and extraction methods.

Main Results:

• DES extraction media are primarily choline chloride-based or natural product-based.
• Extraction yields vary significantly (0.02–200 mg/g) depending on DES composition and method.
• Specific examples include curcumin (23.1 mg/g) and rutin (200 mg/g) extraction.

Conclusions:

• DESs demonstrate significant advantages in extraction efficiency and environmental sustainability.
• Optimal DES selection requires consideration of factors like composition and method.
• Further research is needed to overcome existing limitations in DES applications.