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Exploring Ibuprofen-Menthol Eutectic Systems: Physicochemical Properties and Cytotoxicity for Pharmaceutical
Álvaro Werner1, Estefanía Zuriaga1, Marina Sanz1
1Facultad de Ciencias de la Salud, Universidad San Jorge, Campus Universitario, Autov. A23 km 299, 50830 Villanueva de Gállego, Zaragoza, Spain.
Ibuprofen-menthol eutectic systems were developed to improve drug delivery. Some formulations demonstrated reduced toxicity in specific cell lines, indicating potential for safer pharmaceutical applications.
Area of Science:
- Pharmaceutical Science
- Materials Science
Background:
- Eutectic systems are gaining traction in pharmaceutical research for enhanced drug formulation and delivery.
- Active pharmaceutical ingredients (APIs) often require innovative delivery methods to improve efficacy.
Purpose of the Study:
- To prepare and characterize therapeutic eutectic systems (THEESs) using ibuprofen and menthol.
- To evaluate the physicochemical, rheological, and cytotoxic properties of these novel eutectic systems.
Main Methods:
- Preparation of ibuprofen-menthol eutectic systems at varying molar ratios.
- Assessment of physicochemical properties (density, refractive index, etc.) and rheological behavior.
- Cytotoxicity evaluation using HaCaT and HepG2 cell lines.
Main Results:
- All prepared systems resulted in clear, viscous, monophasic liquids.
- Physicochemical properties exhibited temperature-dependent inverse relationships. Viscosity followed the Vogel-Fulcher-Tammann equation, indicating non-Newtonian behavior.
- Cytotoxicity varied; Ibu-M3 showed reduced toxicity in HaCaT and HepG2 cells compared to pure compounds, while other ratios displayed differential toxicity.
Conclusions:
- Ibuprofen-menthol eutectic systems possess favorable physicochemical and rheological properties for pharmaceutical processing.
- Specific eutectic compositions demonstrate potential for improved biocompatibility, suggesting their utility in developing safer drug formulations.
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