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Baicalein-Loaded Chitosan Films for Local Treatment of Oral Infections
Magdalena Paczkowska-Walendowska1,2, Anna Rył3, Jakub Kwiatek4,5
1Department of Pharmacognosy and Biomaterials, Poznan University of Medical Sciences, Rokietnicka 3, 60-806 Poznan, Poland.
Polymers
|August 28, 2025
Summary
New chitosan films loaded with baicalein offer sustained drug delivery for oral wound healing. These multifunctional biomaterials show promise in regenerative dentistry and periodontal therapy.
Area of Science:
- Biomaterials Science
- Regenerative Medicine
- Oral and Maxillofacial Surgery
Background:
- Oral infections and tissue defects present ongoing clinical challenges.
- Localized, sustained, and multifunctional therapies are needed for oral and maxillofacial applications.
Purpose of the Study:
- To develop and characterize baicalein-loaded chitosan films as novel biomaterials for oral applications.
- To evaluate the films' drug release kinetics, mechanical properties, and therapeutic activities.
Main Methods:
- A 3^2 factorial design was used to prepare nine chitosan film formulations.
- Characterization included physicochemical analyses (SEM, FTIR, XRPD), mechanical testing, and dissolution studies.
- Evaluation involved 3D anatomical models, biocompatibility assays, and antibacterial testing against Streptococcus mutans.
Main Results:
- Films exhibited uniform baicalein distribution and matrix compatibility.
- Zero-order baicalein release kinetics were observed, influenced by chitosan properties.
- The optimal formulation demonstrated excellent adaptability, stability, antioxidant, anti-inflammatory, and antibacterial activities.
Conclusions:
- Baicalein-loaded chitosan films show potential as multifunctional membranes for regenerative dentistry, periodontal therapy, and peri-implant care.
- The formulation design allows for future integration of bioactive agents for personalized wound healing solutions.
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