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Recent Advance in Electrochemical Chiral Recognition Based on Biomaterials (2019-2024)
Shan Qiu1, Guo-Ying Chen1, Yi-Dan Qin1
1School of Chemistry and Chemical Engineering, Chongqing University, Chongqing 401331, China.
Molecules (Basel, Switzerland)
|August 28, 2025
Summary
This review highlights biomaterials for electrochemical chiral sensors, crucial for analyzing enantiomers in pharmaceuticals and food. These sensors offer sensitive and selective chiral recognition, advancing biomedical applications.
Area of Science:
- Analytical Chemistry
- Biomaterials Science
- Electrochemistry
Background:
- Chirality is vital in biological systems, with enantiomers often showing different pharmacological effects.
- Accurate chiral analysis is essential for pharmaceutical engineering, biomedicine, and food safety.
- Electrochemical chiral recognition offers advantages like simplicity, speed, and low cost.
Purpose of the Study:
- To review research progress in electrochemical chiral recognition using biomaterials from 2019-2024.
- To discuss chiral recognition mechanisms and electrochemical methods.
- To explore challenges and future prospects of biomaterial-based electrochemical chiral sensors.
Main Methods:
- Focus on biomaterials (amino acids, proteins, nucleic acids, polysaccharides) as recognition elements.
- Review of electrochemical detection techniques for chiral compounds.
- Analysis of research trends and advancements in the field.
Main Results:
- Biomaterials are effective for constructing electrochemical chiral sensors due to inherent chirality and biocompatibility.
- Significant progress has been made in developing selective and sensitive chiral sensors.
- Various biomaterial-based sensors demonstrate potential for enantiomer recognition.
Conclusions:
- Biomaterial-based electrochemical sensors are promising for sensitive and selective enantiomer recognition.
- Further research is needed to address challenges and optimize sensor performance.
- This review provides a valuable reference for developing advanced electrochemical chiral sensors.
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