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Published on: October 20, 2023
Cytotoxic Peptidic Metabolites Isolated from the Soil-Derived Fungus Trichoderma atroviride
Jun Gu Kim1, Jae Sang Han1, Dahyeon Lee2
1College of Pharmacy, Chungbuk National University, Cheongju 28160, Republic of Korea.
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Twelve undescribed peptidic compounds, bukhansantaibols A-K (1-10) and bukhansantaibals A-B (11-12), were isolated from the soil fungus Trichoderma atroviride through LC-MS and bioactivity-guided purification. Their structures were elucidated by the analysis of 1D and 2D NMR spectra, HRESIMS, and acid hydrolysis using modified Marfey's method. All compounds were evaluated for their cytotoxic activity against HCT-8 (colon cancer) and SK-OV-3 (ovarian cancer) cells. Among them, compounds 1-5 exhibited significant inhibitory effects, with IC50 values ranging from 2.1 to 19.6 μM.

