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Related Experiment Video

Updated: Sep 9, 2025

Author Spotlight: Advancements in Nanoparticle Technology for Drug Delivery and Immunotherapy

Author Spotlight: Advancements in Nanoparticle Technology for Drug Delivery and Immunotherapy

Published on: November 10, 2023

Nanoparticles for Cancer Immunotherapy: Innovations and Challenges.

Mohannad M Fallatah¹, Ibrahim Alradwan¹, Nojoud Alfayez¹

¹Advanced Diagnostics and Therapeutics Institute, Health Sector, King Abdulaziz City for Science and Technology (KACST), Riyadh 11442, Saudi Arabia.

Pharmaceuticals (Basel, Switzerland)

|August 28, 2025

Summary

Novel drug delivery systems enhance cancer immunotherapy by improving effectiveness and safety. These targeted approaches, using nanoparticles and exosomes, aim to overcome treatment limitations and resistance for better patient outcomes.

Keywords:

cancer immunotherapy drug delivery nanoparticles

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Area of Science:

Oncology
Immunology
Nanotechnology
Biomedical Engineering

Background:

Cancer treatment is evolving with immunotherapies that leverage the host immune system against tumors.
Current immunotherapies show promise but face challenges like limited patient response, off-target effects, immune evasion, and poor pharmacokinetics.

Purpose of the Study:

To review recent advancements in targeted drug delivery systems for cancer immunotherapy.
To explore the application of nanoparticles, liposomes, exosomes, and Wharton's jelly-derived macrovesicles in enhancing immune cell function and overcoming therapeutic resistance.
To identify and discuss current challenges in biocompatibility, scalability, and regulatory aspects of these delivery systems.

Main Methods:

Literature review focusing on targeted drug delivery systems in cancer immunotherapy.
Analysis of nanoparticles, liposomes, exosomes, and Wharton's jelly-derived macrovesicles as drug delivery vehicles.
Characterization of challenges and proposed solutions for engineering and regulatory hurdles.

Main Results:

Targeted delivery systems show potential to improve the efficacy and safety of cancer immunotherapy.
Nanoparticles, liposomes, exosomes, and macrovesicles can enhance immune cell activity and overcome resistance mechanisms.
Biocompatibility, scalability, and regulatory approval remain significant challenges for clinical translation.

Conclusions:

Integrating advanced drug delivery systems with cancer immunotherapy offers a promising strategy for more effective and safer cancer treatment.
Addressing current challenges is crucial for the successful clinical implementation of these novel therapeutic approaches.
This review bridges drug delivery innovation and immunotherapy advancements, providing insights for future cancer therapy development.