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Related Concept Videos

Drug Delivery: Miscellaneous Routes01:22

Drug Delivery: Miscellaneous Routes

467
Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection,  and rectal administration provide localized effects with reduced toxicity.
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
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Drug Delivery: Overview01:16

Drug Delivery: Overview

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The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
422

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Related Experiment Video

Updated: Sep 9, 2025

Fabrication and Characterization of a Conformal Skin-like Electronic System for Quantitative, Cutaneous Wound Management
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Self-Driven, Stretchable Drug Delivery Electronics for Acne Treatment.

Yiming Liu1,2,3, Xingcan Huang2, Qiang Zhang2,4

  • 1Macao Institute of Materials Science and Engineering (MIMSE), Faculty of Innovation Engineering, Macau University of Science and Technology, 999078 Taipa, Macau, China.

ACS Nano
|August 28, 2025
PubMed
Summary

This study introduces a stretchable, self-powered drug delivery system for acne treatment using clindamycin. This innovative device combats bacterial resistance by enabling controlled topical antibiotic delivery, improving treatment efficacy and wearability.

Keywords:
acne treatmentbiocompatible batterydrug deliverystretchable batterywearable electronics

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Area of Science:

  • Biomedical Engineering
  • Materials Science
  • Dermatology

Background:

  • Acne vulgaris is a prevalent skin condition affecting adolescents and adults, leading to physical and psychological distress.
  • Topical antibiotics are common acne treatments but prolonged use causes bacterial resistance.
  • Existing treatments face challenges in efficacy and patient compliance.

Purpose of the Study:

  • To develop a novel, stretchable, self-driven drug delivery system for targeted acne treatment.
  • To overcome bacterial resistance associated with conventional topical antibiotic therapies.
  • To enhance patient compliance through a comfortable and wearable device.

Main Methods:

  • Developed a stretchable, biocompatible drug delivery system powered by a magnesium-O2 battery.
  • Embedded clindamycin as the active antibacterial agent.
  • Utilized ion electrophoresis for controlled drug release, adjustable via battery power output.
  • Validated the system's performance and biocompatibility through in vitro and in vivo studies.

Main Results:

  • The system demonstrated a high stretchability (up to 100%) and biocompatibility.
  • Controllable delivery of clindamycin to target acne lesions was achieved.
  • In vitro and in vivo experiments confirmed the system's feasibility for acne treatment.
  • The device effectively extended antibiotic efficacy while ensuring long-term wearability.

Conclusions:

  • The developed stretchable, self-driven system offers a promising solution for acne treatment.
  • This technology addresses bacterial resistance and improves therapeutic outcomes.
  • The system's design enhances wearability and patient compliance for sustained acne management.