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Microbiota Analysis Using Two-step PCR and Next-generation 16S rRNA Gene Sequencing
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Deciphering the Potential Causal and Prognostic Relationships Between Gut Microbiota and Brain Tumors: Insights from
Changwu Wu1,2,3,4, Fushu Luo1, Yongye Zhu1
1Department of Neurosurgery Xiangya Hospital Central South University Changsha Hunan China.
Exploration (Beijing, China)
|August 28, 2025
Summary
This study confirms gut microbes causally influence brain tumors like meningioma, pituitary tumors, and glioma. A new microbe-related signature (MRS) model predicts glioma prognosis and immunotherapy response.
Area of Science:
- Neuroscience
- Microbiology
- Oncology
Background:
- Observational studies suggest gut microbiota dysbiosis in brain tumor patients.
- The causal link and prognostic value of gut microbiota in brain tumors remain unclear.
Purpose of the Study:
- To investigate the causal relationship between gut microbes and brain tumors.
- To identify microbe-related genes (MRGs) and develop a prognostic model for brain tumors.
Main Methods:
- Multiple Mendelian randomization analyses were used to establish causal effects.
- The Sherlock framework identified microbe-related genes (MRGs) in brain tissues.
- Machine learning was employed to build a microbe-related signature (MRS) prognostic model.
Main Results:
- Causal effects of specific gut microbes on meningioma, pituitary tumor, and glioma were confirmed.
- 103 meningioma-MRGs, 40 pituitary tumor-MRGs, and 63 glioma-MRGs were identified.
- Glioma-related MRGs correlated with tumor grade and prognosis; the MRS model predicted glioma prognosis and immunotherapy benefits.
Conclusions:
- Gut microbiota causally impacts brain tumor development.
- The identified MRGs and the MRS model offer potential biomarkers for glioma prognosis and treatment response evaluation.
