Related Experiment Video
Updated: Sep 9, 2025

The Use of a β-lactamase-based Conductimetric Biosensor Assay to Detect Biomolecular Interactions
Published on: February 1, 2018
[Beta-lactams and beta-lactamase inhibitors-current developments]
Winfried V Kern1, Sören G Gatermann2
1Klinik für Innere Medizin II/Abteilung Infektiologie, Universitätsklinikum Freiburg, Hugstetter Str. 55, 79106, Freiburg, Deutschland. winfried.kern@uniklinik-freiburg.de.
Recent advancements in antibacterial drugs focus on beta-lactams and beta-lactamase inhibitors. New agents like cefiderocol and combinations target resistant Gram-negative bacteria, with potential for oral treatments in the future.
Area of Science:
- Pharmacology and Microbiology
- Medicinal Chemistry
Context:
- Significant progress in developing novel antibacterial agents, particularly within the beta-lactam class.
- Focus on combating antibiotic resistance through advanced drug design and combination therapies.
Purpose:
- To review recent developments in antibacterial substances, emphasizing beta-lactams and beta-lactamase inhibitors.
- To highlight new agents and combinations effective against resistant Gram-negative bacteria and explore future oral treatment possibilities.
Summary:
- New beta-lactamase inhibitors and combinations, such as ceftazidime-avibactam and cefiderocol, show efficacy against multidrug-resistant Gram-negative pathogens.
- Cefiderocol utilizes bacterial iron uptake systems for enhanced delivery.
- Boronate-based inhibitors offer broad-spectrum activity against various beta-lactamases, including metallo-beta-lactamases.
Impact:
- These developments offer new therapeutic options for challenging infections caused by resistant bacteria.
- Future oral beta-lactam and combination therapies could revolutionize treatment for mycobacteriosis and ESBL-producing bacterial infections.
More Related Videos
12:03Antimicrobial Synergy Testing by the Inkjet Printer-assisted Automated Checkerboard Array and the Manual Time-kill Method
Published on: April 18, 2019
11:15Quadruple-Checkerboard: A Modification of the Three-Dimensional Checkerboard for Studying Drug Combinations
Published on: July 24, 2021
Related Concept Videos
Development of Antibiotic Resistance
Combined Effects of Drugs: Synergism
Such synergistic combinations...
Acute Pyelonephritis II: Diagnostic Studies and Management
Antibiotic Selection
Microorganisms in Medicine and Therapeutics
Urine Studies II: Urine Culture and Sensitivity Test