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Engineered Probiotic-Powered Micro-Rod Robot Bomb for Thrombus-Penetrating Explosion
Riyue Liu1, Jiale Chen1,2, Yuanyuan Li1,2
1Xiamen Cardiovascular Hospital of Xiamen University, School of Medicine, Fujian Branch of National Clinical Research Center for Cardiovascular Diseases, Xiamen, 361006, China.
Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
|August 28, 2025
Summary
Engineered probiotic micro-robots offer targeted thrombus treatment. These robots precisely deliver drugs, penetrate clots deeply, and enhance therapeutic durability for vascular injury disorders.
Area of Science:
- Biomedical Engineering
- Nanotechnology
- Microbiology
Background:
- Conventional thrombolytic agents have limited efficacy due to narrow therapeutic windows and progressive vascular injury.
- Current treatments lack precision, timeliness, and treatment durability for thrombotic disorders.
Purpose of the Study:
- To develop an engineered probiotic-powered micro-rod robot for targeted and penetrative thrombus treatment.
- To enhance thrombolysis efficiency, drug delivery precision, and treatment durability.
Main Methods:
- Development of a micro-rod robot (SrEcNPL) using probiotics as bio-carriers.
- Functionalization with thrombolytic carbon nanotubes and platelet membrane-coated nanoparticles loaded with vasodilators.
- Exploitation of probiotic movement and platelet membrane targeting for precise drug delivery and deep thrombus penetration.
Main Results:
- The micro-robot achieved rapid and precise drug delivery to thrombus tissue.
- Deep penetration into thrombus tissue led to faster thrombolysis efficiency.
- Extended the biological half-life of thrombolytic drugs by approximately 332 times, enabling sustained thrombolysis and inhibiting secondary thrombus formation.
Conclusions:
- The novel dual-pronged thrombolytic therapy demonstrates significant potential for treating thrombotic diseases.
- The engineered micro-robot offers a precise, timely, and durable treatment approach for vascular injury.
- This approach has significant scientific implications for managing thrombotic disorders with narrow therapeutic windows.
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