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Updated: Sep 9, 2025

Digital Planimetry for Assessing Wound Closure Kinetics in a Mouse Model
Published on: January 10, 2025
Global landscape and translational trajectories of flavonoid-based wound-healing research
Lin Chen1, Xiaofeng Yin2, Aifa Tang3
1Department of Urology, Affiliated Hospital of Chengdu University, Chengdu, Sichuan 610081, China.
Abstract:
Flavonoids have antioxidant, anti-inflammatory, and antimicrobial properties, making them promising agents in wound healing. This scientometric analysis examined 3416 articles (2005-2024) from the Web of Science using CiteSpace, VOSviewer, and R to map global trends, collaborations, mechanisms, and translational pathways. PubMed was also searched to examine patterns in clinical research, encompassing both randomized controlled trials (|RCTs) and observational studies. China contributed 25.8% of publications, followed by India (14.8%) and the USA (10.5%). Research focus has shifted from phytochemistry to clinically oriented studies, with quercetin, hesperidin, luteolin, diosmetin, and naringenin emerging as leading compounds linked to nanoformulations and hydrogel composites. These results provide a quantitative roadmap for advancing flavonoid-based wound therapeutics toward clinical application.
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